4-hydroxybenzaldehyde dehydrogenase explained

4-hydroxybenzaldehyde dehydrogenase
Ec Number:	1.2.1.64
Go Code:	0018484

In enzymology, a 4-hydroxybenzaldehyde dehydrogenase is an enzyme that catalyzes the chemical reaction

4-hydroxybenzaldehyde + NAD⁺ + H₂O

\rightleftharpoons 4-hydroxybenzoate + NADH + 2 H⁺

The 3 substrates of this enzyme are 4-hydroxybenzaldehyde, NAD⁺, and H₂O, whereas its 3 products are 4-hydroxybenzoate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-hydroxybenzaldehyde:NAD+ oxidoreductase. This enzyme is also called p-hydroxybenzaldehyde dehydrogenase. This enzyme participates in toluene and xylene degradation in bacteria.^{[1] [2]} It is also found in carrots (Daucus carota).^[3]

Notes and References

1. Bossert ID, Whited G, Gibson DT, Young LY . 1989 . Anaerobic oxidation of p-cresol mediated by a partially purified methylhydroxylase from a denitrifying bacterium . J. Bacteriol. . 171 . 2956 - 62 . 2722739 . 6 . 210000 .
2. Whited GM, Gibson DT . 1991 . Separation and partial characterization of the enzymes of the toluene-4-monooxygenase catabolic pathway in Pseudomonas mendocina KR1 . J. Bacteriol. . 173 . 3017 - 20 . 2019564 . 9 . 207886 .
3. Sircar . D. . Mitra . A. . 10.1016/j.jplph.2007.05.005 . Evidence for p-hydroxybenzoate formation involving enzymatic phenylpropanoid side-chain cleavage in hairy roots of Daucus carota . Journal of Plant Physiology . 165 . 4 . 407–414 . 2008 . 17658659.