Oxypertine Explained

Oxypertine (Equipertine, Forit, Integrin, Lanturil, Lotawin, Opertil) is an antipsychotic used in the treatment of schizophrenia.^[1] It was also evaluated for the treatment of anxiety at a dosage of 20 mg per day.^[2] Chemically, it is an indole and phenylpiperazine derivative.^[3] Like reserpine and tetrabenazine, oxypertine depletes catecholamines, though not serotonin, possibly underlying its neuroleptic efficacy.^[4] Its structure is similar to solypertine and milipertine.

See also

• Monoamine-depleting agent

Notes and References

1. Book: Dictionary of organic compounds . Chapman & Hall . London . 1996 . 0-412-54090-8 . Hall C, Rhodes PH .
2. Somohano MD, Broissin MC, Sobrino ZA . [Clinical evaluation of oxypertine in anxiety conditions] . es . Neurologia, Neurocirugia, Psiquiatria . 17 . 3 . 171–180 . 1976 . 12484 .
3. Breulet M, Labar P, Delree C, Collard J, Bobon J . [Oxypertine, peperazine derivative of tryptophan with neuroleptic and dynamogenic properties] . fr . Acta Neurologica et Psychiatrica Belgica . 68 . 2 . 116–127 . February 1968 . 4972600 .
4. Bak IJ, Hassler R, Kim JS . Differential monoamine depletion by oxypertine in nerve terminals. Granulated synaptic vesicles in relation to depletion of norepinephrine, dopamine and serotonin . Zeitschrift für Zellforschung und Mikroskopische Anatomie . 101 . 3 . 448–462 . 1969 . 5362847 . 10.1007/BF00335580 . 32583722 .