Oxoglutarate dehydrogenase (NADP+) explained

oxoglutarate dehydrogenase (NADP+)
Ec Number:	1.2.1.52
Cas Number:	126469-85-0
Go Code:	0050164

In enzymology, an oxoglutarate dehydrogenase (NADP+) is an enzyme that catalyzes the chemical reaction

2-oxoglutarate + CoA + NADP⁺

\rightleftharpoons succinyl-CoA + CO₂ + NADPH

The 3 substrates of this enzyme are 2-oxoglutarate, CoA, and NADP⁺, whereas its 3 products are succinyl-CoA, CO₂, and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating). This enzyme is also called oxoglutarate dehydrogenase (NADP+).

References

• Inui H, Miyatake K, Nakano Y, Kitaoka S . Tokyo . Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis . J. Biochem. . 96. 931 - 4 . 6438078 . 3 . September 1984 . 10.1093/oxfordjournals.jbchem.a134913.