Oxamic acid explained

Oxamic acid is an organic compound with the formula . It is a white, water-soluble solid. It is the monoamide of oxalic acid.^[1] Oxamic acid inhibits lactate dehydrogenase A.^[2] The active site of lactate dehydrogenase (LDH) is closed off once oxamic acid attaches to the LDH-NADH complex, effectively inhibiting it.^[3]

Oxamic acid also has applications in polymer chemistry. It increases the water solubility of certain polymers, including polyester, epoxide, and acrylic upon binding with them.^[4]

See also

• Oxamate, the conjugate base of oxamic acid

Notes and References

1. Web site: Oxamic acid . PubChem . National Center for Biotechnology Information, U.S. National Library of Medicine . 2016-12-14 . 2016-12-01 . https://web.archive.org/web/20161201014207/https://pubchem.ncbi.nlm.nih.gov/compound/oxamic_acid#section=Depositor-Supplied-Synonyms . live .
2. Miskimins WK, Ahn HJ, Kim JY, Ryu S, Jung YS, Choi JY . Synergistic anti-cancer effect of phenformin and oxamate . PLOS ONE . 9 . 1 . e85576 . 2014 . 24465604 . 3897486 . 10.1371/journal.pone.0085576 . free .
3. Raczyńska. Ewa D.. Hallmann. Małgorzata. Duczmal. Kinga. March 2011. Quantum-chemical studies of amide–iminol tautomerism for inhibitor of lactate dehydrogenase: Oxamic acid. Computational and Theoretical Chemistry. 964. 1–3. 310–317. 10.1016/j.comptc.2011.01.017. 2210-271X.
4. Zarzyka-Niemiec. Iwona. 2008-10-05. Hydroxyalkylation of oxamic acid with propylene carbonate: Synthesis, composition, and properties of products. Journal of Applied Polymer Science. 110. 1. 66–75. 10.1002/app.28609. 0021-8995.