Oxacephem Explained

An oxacephem is a β-lactam molecule similar to a cephem, but with an oxygen substituted for the sulfur. They are synthetic compounds not seen in nature, generally used as β-lactam antibiotics. Examples include Latamoxef^[1] and Flomoxef.^{[2] [3]}

Notes and References

1. Web site: Medscape.com . 2008-12-29.
2. Yazawa K, Mikami Y, Uno J, Otozai K, Arai T . In-vitro activity of flomoxef, a new oxacephem group antibiotic, against Nocardia in comparison with other cephalosporins . J. Antimicrob. Chemother. . 24 . 6 . 921–5 . December 1989 . 2621177 . 10.1093/jac/24.6.921.
3. Cazzola M, Brancaccio V, De Giglio C, Paternò E, Matera MG, Rossi F . Flomoxef, a new oxacephem antibiotic, does not cause hemostatic defects . Int J Clin Pharmacol Ther Toxicol . 31 . 3 . 148–52 . March 1993 . 8468113 .