Organotellurium chemistry explained

Organotellurium chemistry describes the synthesis and properties of organotellurium compounds, chemical compounds containing a carbon-tellurium chemical bond. Organotellurium chemistry is a lightly studied area, in part because of it having few applications.[1] [2]

Functional groups

The tellurium analogues of common organosulfur and organoselenium functional groups are known. Tellurols are however unstable with respect to oxidation to the ditellurides. Commonly encountered organotellurium compounds are diorganomono- and ditellurides, R2Te and (RTe)2, respectively. Two other families of organotellurium(IV) compounds are well developed: R4−xTeClx and the telluroxides (R2TeO).

Synthesis and reactions

Reduced organotellurium compounds

Reduced organotellurium compounds are commonly obtained from NaHTe and lithium telluride:

Li2Te + 2 RBr → R2Te + 2 LiBrA direct route to organolithium compounds starts from reactions of organolithium or Grignard reagents and Te:

Te + ArLi → ArTeLiButyl lithium gives the telluride similarly:[3]

Te + BuLi → BuTeLi

Organotelluride anions can be oxidized or alkylated:

2 RTeLi + 0.5 O2 + H2O → RTeTeR + 2 LiOH

RTeLi + R'Br → RTeR' + LiBr

Diorganoditellurides are valued intermediates, especially the aryl derivatives such as diphenyl ditelluride:

Ar2Te2 + RLi → RTeAr + LiTeR

Ph2Te2 + 2 Li → 2 LiTePh

Derivatives of TeCl4

One departure from sulfur and selenium chemistry is the availability of the tetrachloride, TeCl4.[4] It reacts with arenes to give aryltellurium trichlorides:[5]

ArH + TeCl4 → ArTeCl3 + HClFor electron-rich arenes, the disubstitution occurs

ArH + ArTeCl3 → Ar2TeCl2 + HCl

Tellurium tetrachloride adds across alkenes and alkynes to the chloro tellurium trichlorides:

RCH=CH2 + TeCl4 → RCH(Cl)-CH2TeCl3

Organotellurium trichlorides adopt dimeric structures, reflecting the Lewis acidity of the Te(IV) center. The dimers are cleaved by halides and other Lewis bases:[6]

RTeCl3 + Cl → RTeCl4The anions RTeCl4 (and the related adducts RTeCl3L) adopt square pyramidal structures with the electronegative groups in the plane.

Organotellurium(IV) chlorides are susceptible to substitution reactions where by chloride is replaced by other halides and pseudohalides. The TeClx group can also be removed with Raney nickel.[5]

Organotellurium(IV) compounds participate in Stille reactions:[7]

Telluroxides

Telluroxides are generally related to sulfoxides and selenoxides in terms of their structures. Unlike their lighter analogues however, they polymerize (reversibly) when crystallized. Analogous to selenoxide oxidation, allylic telluroxides undergo [2,3]-sigmatropic rearrangements forming allylic alcohols after hydrolysis. Also analogous to the selenoxide elimination, certain telluroxides give alkenes upon heating.

Te(VI)

Hexamethylpertellurane was prepared by oxidation of tetramethyltellurium with xenon difluoride.[8] The resulting TeF2(CH3)4 is then treated with dimethylzinc:

The octahedral compounds TeAr6 have also been prepared.[9]

Applications

Dimethyl telluride is used to in metalorganic vapour phase epitaxy where it serves as a volatile source of Te. It is the only organotellurium compound that has been quantified in environmental samples.[10]

Telluroethers undergo a variant of the selenoxide elimination.[11]

Notes and References

  1. Nicola Petragnani, Tellurium in Organic Synthesiss 1994, Academic Press, New York.
  2. M. Detty, M. O'Regan, Tellurium-Containing Heterocycles., John Wiley & Sons, Inc., New York, 1994
  3. 10.15227/orgsyn.072.0154. Generation of N,N-Diethylcarbamoyllithium Via Lithium-Tellurium Exchange and Its Reaction with 3-Phenylpropanal: N,N-Diethyl-2-Hydroxy-4-Phenylbutanamide. Organic Syntheses. 1995. 72. 154. Nobuaki Kambe, Toru Inoue, Noboru Sonoda.
  4. Lars Engman, "Tellurium(IV) Chloride" E-EROS. 2001.
  5. 10.15227/orgsyn.057.0018. Biaryls from Simple Arenes via Organotellurium Intermediates: 4,4'-Dimethoxy-1,1'-biphenyl. Organic Syntheses. 1977. 57. 18. J. Bergman, R. Carlsson, B. Sjöberg.
  6. 10.1021/ic062469m. Four Distinctively Different Decomposition Pathways of Metastable Supermesityltellurium(IV) Trichloride. 2007. Beckmann. Jens. Heitz. Stephan. Hesse. Malte. Inorganic Chemistry. 46. 8. 3275–3282. 17375915.
  7. Palladium- and copper-catalyzed cross-coupling and carbonylative cross-coupling of organotellurium compounds with organostannanes (Chem. Commun. 1999, 2117) - Royal Society of Chemistry Suk-Ku Kang, Sang-Woo Lee and Hyung-Chul Ryu Link
  8. Synthesis and characterization of hexamethyltellurium(VI). Latif. Ahmed. John A.. Morrison. J. Am. Chem. Soc.. 1990. 112. 20 . 7411–7413. 10.1021/ja00176a061.
  9. 10.1002/chem.200305260 . Syntheses and Reactions of Hexavalent Organotellurium Compounds Bearing Five or Six Tellurium-Carbon Bonds . 2004 . Miyasato . Masataka . Sagami . Takao . Minoura . Mao . Yamamoto . Yohsuke . Akiba . Kin-ya . Chemistry – A European Journal . 10 . 10 . 2590–2600 . 15146530 .
  10. Book: Wallschläger, D.. Feldmann, F. . Formation, Occurrence, Significance, and Analysis of Organoselenium and Organotellurium Compounds in the Environment. RSC Publishing. 2010. Metal Ions in Life Sciences. 7, Organometallics in Environment and Toxicology. 319–364. 978-1-84755-177-1.
  11. Encyclopedia: 10.1002/047084289X.rd416. Diphenyl ditelluride. David. Crich. Yao Qingwei. Encyclopedia of Reactants for Organic Synthesis.