Olivetolic acid cyclase explained

Olivetolic acid cyclase
Ec Number:	4.4.1.26

Olivetolic acid cyclase (EC 4.4.1.26, OAC) is an enzyme with systematic name 3,5,7-trioxododecanoyl-CoA CoA-lyase (2,4-dihydroxy-6-pentylbenzoate-forming).^[1] This enzyme catalyses the following chemical reaction

3,5,7-trioxododecanoyl-CoA → CoA + 2,4-dihydroxy-6-pentylbenzoate

This enzymes participates in the cannabinoids biosynthesis in the plant Cannabis sativa.

Notes and References

1. Gagne SJ, Stout JM, Liu E, Boubakir Z, Clark SM, Page JE . Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides . Proceedings of the National Academy of Sciences of the United States of America . 109 . 31 . 12811–6 . July 2012 . 22802619 . 3411943 . 10.1073/pnas.1200330109 . 2012PNAS..10912811G . free .