Oligopeptidase A Explained

Oligopeptidase A
Ec Number:3.4.24.70
Cas Number:394250-11-4

Oligopeptidase A (68000-M signalpeptide hydrolase) is an enzyme.[1] [2] [3] [4] This enzyme catalyses the following chemical reaction

Hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-Gly-Pro-Ala is cleaved, but not Z-(Gly)5

This enzyme is known from Escherichia coli and Salmonella typhimurium.

Notes and References

  1. Novak P, Dev IK . Degradation of a signal peptide by protease IV and oligopeptidase A . Journal of Bacteriology . 170 . 11 . 5067–75 . November 1988 . 3053642 . 211572 . 10.1128/jb.170.11.5067-5075.1988 .
  2. Conlin CA, Vimr ER, Miller CG . Oligopeptidase A is required for normal phage P22 development . Journal of Bacteriology . 174 . 18 . 5869–80 . September 1992 . 1522065 . 207121 . 10.1128/jb.174.18.5869-5880.1992 .
  3. Conlin CA, Trun NJ, Silhavy TJ, Miller CG . Escherichia coli prlC encodes an endopeptidase and is homologous to the Salmonella typhimurium opdA gene . Journal of Bacteriology . 174 . 18 . 5881–7 . September 1992 . 1325967 . 207123 . 10.1128/jb.174.18.5881-5887.1992 .
  4. Book: Conlin CA, Miller CG . Dipeptidyl carboxypeptidase and oligopeptidase A from Escherichia coli and Salmonella typhimurium . Methods in Enzymology . 248 . 567–79 . 1995 . 7674945 . 10.1016/0076-6879(95)48036-6 .

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