Octanoyl-(GcvH):protein N-octanoyltransferase explained

Octanoyl-(GcvH):protein N-octanoyltransferase
Ec Number:	2.3.1.204

Octanoyl-(GcvH):protein N-octanoyltransferase (LIPL, octanoyl-[GcvH]:E2 amidotransferase, YWFL (gene)) is an enzyme with systematic name (glycine cleavage system H)-N⁶-octanoyl-L-lysine:(lipoyl-carrier protein)-N⁶-L-lysine octanoyltransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

[glycine cleavage system H]-N⁶-octanoyl-L-lysine + [lipoyl-carrier protein]

\rightleftharpoons glycine cleavage system H + [lipoyl-carrier protein]-N⁶-octanoyl-L-lysine

This enzyme is purified from the bacterium Bacillus subtilis.

Notes and References

1. Christensen QH, Martin N, Mansilla MC, de Mendoza D, Cronan JE . A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis . Molecular Microbiology . 80 . 2 . 350–63 . April 2011 . 21338421 . 3088481 . 10.1111/j.1365-2958.2011.07598.x .
2. Martin N, Christensen QH, Mansilla MC, Cronan JE, de Mendoza D . A novel two-gene requirement for the octanoyltransfer reaction of Bacillus subtilis lipoic acid biosynthesis . Molecular Microbiology . 80 . 2 . 335–49 . April 2011 . 21338420 . 3086205 . 10.1111/j.1365-2958.2011.07597.x .