O-aminophenol oxidase explained
| o-Aminophenol oxidase |
| Ec Number: | 1.10.3.4 |
| Cas Number: | 9013-85-8 |
o-Aminophenol oxidase (isophenoxazine synthase, o-aminophenol:O2 oxidoreductase, 2-aminophenol:O2 oxidoreductase, GriF) is an enzyme with systematic name 2-aminophenol:oxygen oxidoreductase.[1] [2] [3] [4] This enzyme catalyses the following chemical reaction
2 o-aminophenol + O2 + acceptor 2-aminophenoxazin-3-one + reduced acceptor + 2 H2O (overall reaction)
(1a) 2 2-aminophenol + O2 2 6-iminocyclohexa-2,4-dienone + 2 H2O
(1b) 2 6-iminocyclohexa-2,4-dienone + acceptor 2-aminophenoxazin-3-one + reduced acceptor (spontaneous)
o-Aminophenol oxidase is a flavoprotein.
Notes and References
- Nair PM, Vaidyanathan CS . Isophenoxazine synthase . Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects . 81 . 507–16 . March 1964 . 3 . 14170322 . 10.1016/0926-6569(64)90135-x .
- Nair PM, Vining LC . Isophenoxazine synthase apoenzyme from Pycnoporus coccineus . Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation . 96 . 318–27 . February 1965 . 2 . 14298835 . 10.1016/0926-6593(65)90015-9 .
- Subba Rao PV, Vaidyanathan CS . Studies on the metabolism of o-aminophenol. Purification and properties of isophenoxazine synthase from Bauhenia monandra . Archives of Biochemistry and Biophysics . 118 . 2 . 388–94 . February 1967 . 4166439 . 10.1016/0003-9861(67)90365-7 .
- Suzuki H, Furusho Y, Higashi T, Ohnishi Y, Horinouchi S . A novel o-aminophenol oxidase responsible for formation of the phenoxazinone chromophore of grixazone . The Journal of Biological Chemistry . 281 . 2 . 824–33 . January 2006 . 16282322 . 10.1074/jbc.M505806200 . free .
