Nucleus reuniens explained

Nucleus reuniens
Latin:nucleus reuniens

The nucleus reuniens is a region of the thalamic midline nuclear group.[1] [2] In the human brain, it is located in the interthalamic adhesion (massa intermedia).[3] [4]

The nucleus reuniens receives afferent input from a large number of structures, mainly from limbic and limbic-associated structures.[5] It sends projections to the medial prefrontal cortex, the hippocampus, perirhinal cortex, and entorhinal cortex,[6] [7] [8] although there exist sparse connections to many other afferent structures as well.[9]

The unique medial prefrontal cortex and hippocampal connectivity allows reuniens to regulate neural traffic in this cortical network related to changes in an organism's attentiveness,[10] making reuniens critical to associative learning,[11] memory retrieval,[12] memory generalization,[13] spatial route planning,[14] and resilience to stress.[15]

Notes and References

  1. Dolleman-van der Weel . Margriet J. . Griffin . Amy L. . Ito . Hiroshi T. . Shapiro . Matthew L. . Witter . Menno P. . Vertes . Robert P. . Allen . Timothy A. . 2019 . The nucleus reuniens of the thalamus sits at the nexus of a hippocampus and medial prefrontal cortex circuit enabling memory and behavior . Learning & Memory . en . 26 . 7 . 191–205 . 10.1101/lm.048389.118 . 1549-5485 . 6581009 . 31209114.
  2. Griffin. Amy L.. 2015-01-01. Role of the thalamic nucleus reuniens in mediating interactions between the hippocampus and medial prefrontal cortex during spatial working memory. Frontiers in Systems Neuroscience. English. 9. 29. 10.3389/fnsys.2015.00029. 1662-5137. 4354269. 25805977. free.
  3. Book: Carpenter. Malcolm. Sutin. Jerome. Human Neuroanatomy. 1983. Williams & Wilkins. Baltimore. 978-0-683-01461-7. 504–510.
  4. Reeders . Puck C. . Rivera Núñez . M. Vanessa . Vertes . Robert P. . Mattfeld . Aaron T. . Allen . Timothy A. . 2023-01-04 . Identifying the midline thalamus in humans in vivo . Brain Structure and Function . en . 10.1007/s00429-022-02607-6 . 36598561 . 1863-2661.
  5. McKenna . J. T. . Vertes . R. P. . 10.1002/cne.20342 . Afferent projections to nucleus reuniens of the thalamus . The Journal of Comparative Neurology . 480 . 2 . 115–142 . 2004 . 15514932 . 9284778 .
  6. Wouterlood . F. G. . Saldana . E. . Witter . M. P. . 10.1002/cne.902960202 . Projection from the nucleus reuniens thalami to the hippocampal region: Light and electron microscopic tracing study in the rat with the anterograde tracerPhaseolus vulgaris-leucoagglutinin . The Journal of Comparative Neurology . 296 . 2 . 179–203 . 1990 . 2358531 . 24568442 .
  7. Vertes . R. P. . Interactions among the medial prefrontal cortex, hippocampus and midline thalamus in emotional and cognitive processing in the rat . 10.1016/j.neuroscience.2006.06.027 . Neuroscience . 142 . 1 . 1–20 . 2006 . 16887277 . 5591335 .
  8. Viena . Tatiana D. . Rasch . Gabriela E. . Silva . Daniela . Allen . Timothy A. . 2021 . Calretinin and calbindin architecture of the midline thalamus associated with prefrontal–hippocampal circuitry . Hippocampus . en . 31 . 7 . 770–789 . 10.1002/hipo.23271 . 1050-9631 . 8805340 . 33085824.
  9. Herkenham . M. . The connections of the nucleus reuniens thalami: Evidence for a direct thalamo-hippocampal pathway in the rat . 10.1002/cne.901770405 . The Journal of Comparative Neurology . 177 . 4 . 589–610 . 1978 . 624792 . 7535058 .
  10. Vertes . R. P. . Hoover . W. B. . Szigeti-Buck . K. . Leranth . C. . 2007 . Nucleus reuniens of the midline thalamus: Link between the medial prefrontal cortex and the hippocampus . Brain Research Bulletin . 71 . 6 . 601–609 . 10.1016/j.brainresbull.2006.12.002 . 4997812 . 17292803.
  11. Eleore . L. . López-Ramos . J. C. . Guerra-Narbona . R. . Delgado-García . J. M. . Izquierdo . Ivan . Role of Reuniens Nucleus Projections to the Medial Prefrontal Cortex and to the Hippocampal Pyramidal CA1 Area in Associative Learning . 10.1371/journal.pone.0023538 . PLOS ONE . 6 . 8 . e23538 . 2011 . 21858159. 3156136 . 2011PLoSO...623538E . free .
  12. Jayachandran . Maanasa . Linley . Stephanie B. . Schlecht . Maximilian . Mahler . Stephen V. . Vertes . Robert P. . Allen . Timothy A. . 2019 . Prefrontal Pathways Provide Top-Down Control of Memory for Sequences of Events . Cell Reports . en . 28 . 3 . 640–654.e6 . 10.1016/j.celrep.2019.06.053 . 6662648 . 31315044.
  13. Xu . W. . Sudhof . T. C. . 14 March 2013 . A Neural Circuit for Memory Specificity and Generalization . Science . 339 . 6125 . 1290–1295 . 2013Sci...339.1290X . 10.1126/science.1229534 . 3651700 . 23493706.
  14. 26017312. 2015. Ito. H. T.. A prefrontal-thalamo-hippocampal circuit for goal-directed spatial navigation. Nature. 522. 7554. 50–5. Zhang. S. J.. Witter. M. P.. Moser. E. I.. Moser. M. B.. 10.1038/nature14396. 2015Natur.522...50I. 11250/2493579. 205243449. free.
  15. Kafetzopoulos. V.. Kokras. N.. Sotiropoulos. I.. Oliveira. J. F.. Leite-Almeida. H.. Vasalou. A.. Sardinha. V. M.. Papadopoulou-Daifoti. Z.. Almeida. O. F. X.. 2017-04-11. The nucleus reuniens: a key node in the neurocircuitry of stress and depression. Molecular Psychiatry. 23. 3. 579–586. 10.1038/mp.2017.55. 1476-5578. 28397837. 5822458.

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