Nucleoside oxidase (H2O2-forming) explained

Nucleoside oxidase (H2O2-forming)
Ec Number:	1.1.3.39

Nucleoside oxidase (H₂O₂-forming) is an enzyme with systematic name nucleoside:oxygen 5'-oxidoreductase (H₂O₂-forming).^[1] This enzyme catalyses the following chemical reaction

adenosine + 2 O₂ + H₂O

\rightleftharpoons 9-riburonosyladenine + 2 H₂O₂ (overall reaction)

(1a) adenosine + O₂

\rightleftharpoons 5'-dehydroadenosine + H₂O₂

(1b) 5'-dehydroadenosine + O₂ + H₂O

\rightleftharpoons 9-riburonosyladenine + H₂O₂

This enzyme contains Heme and belongs to a flavoprotein family.

Notes and References

1. Koga S, Ogawa J, Cheng L, Choi Y, Yamada H, Shimizu S . Nucleoside Oxidase, a Hydrogen Peroxide-Forming Oxidase, from Flavobacterium meningosepticum . Applied and Environmental Microbiology . 63 . 11 . 4282–6 . November 1997 . 16535726 . 1389282 .