Nucleoside-triphosphatase explained

nucleoside-triphosphatase
Ec Number:	3.6.1.15
Cas Number:	9075-51-8
Go Code:	0017111

In enzymology, a nucleoside-triphosphatase (NTPase) is an enzyme that catalyzes the chemical reaction

NTP + H₂O

\rightleftharpoons NDP + phosphate

Thus, the two substrates of this enzyme are NTP and H₂O, whereas its two products are NDP and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is unspecific diphosphate phosphohydrolase. Other names in common use include nucleoside triphosphate phosphohydrolase, nucleoside-5-triphosphate phosphohydrolase, and nucleoside 5-triphosphatase. This enzyme participates in purine metabolism and thiamine metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .

References

• Brightwell R, Tappel AL . 1968 . Lysosomal acid pyrophosphatase and acid phosphatase . Arch. Biochem. Biophys. . 124 . 333 - 43 . 5661608 . 10.1016/0003-9861(68)90335-4 . 1 .
• LEWIS M, WEISSMAN S . Properties of a soluble nucleoside triphosphatase activity in mammalian liver . 1965 . Arch. Biochem. Biophys. . 109 . 490 - 8 . 14320490 . 10.1016/0003-9861(65)90393-0 . 3 .
• Matsushita S, Raacke ID . 1968 . Purification of nucleoside triphosphatases from pea seedling ribosomes . Biochim. Biophys. Acta . 166 . 707 - 10 . 4301913 . 3 . 10.1016/0005-2787(68)90380-8.