Nucleolar phosphoprotein p130 explained

Nucleolar phosphoprotein p130 is a protein that in humans is encoded by the NOLC1 gene.^{[1] [2] [3]}

Interactions

Nucleolar phosphoprotein p130 has been shown to interact with coilin^[4] and CEBPB.^[5]

Further reading

• Nomura N, Miyajima N, Sazuka T, etal . Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. . DNA Res. . 1 . 1 . 27–35 . 1995 . 7584026 . 10.1093/dnares/1.1.27 . free .
• Nomura N, Miyajima N, Sazuka T, etal . Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). . DNA Res. . 1 . 1 . 47–56 . 1995 . 7584028 . 10.1093/dnares/1.1.47 . free .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Pai CY, Yeh NH . Cell proliferation-dependent expression of two isoforms of the nucleolar phosphoprotein p130. . Biochem. Biophys. Res. Commun. . 221 . 3 . 581–7 . 1996 . 8630004 . 10.1006/bbrc.1996.0639 .
• Miau LH, Chang CJ, Tsai WH, Lee SC . Identification and characterization of a nucleolar phosphoprotein, Nopp140, as a transcription factor. . Mol. Cell. Biol. . 17 . 1 . 230–9 . 1997 . 8972203 . 10.1128/MCB.17.1.230. 231747 .
• Li D, Meier UT, Dobrowolska G, Krebs EG . Specific interaction between casein kinase 2 and the nucleolar protein Nopp140. . J. Biol. Chem. . 272 . 6 . 3773–9 . 1997 . 9013635 . 10.1074/jbc.272.6.3773 . free .
• Chen HK, Yeh NH . The nucleolar phosphoprotein P130 is a GTPase/ATPase with intrinsic property to form large complexes triggered by F- and Mg2+. . Biochem. Biophys. Res. Commun. . 230 . 2 . 370–5 . 1997 . 9016786 . 10.1006/bbrc.1996.5966 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Miau LH, Chang CJ, Shen BJ, etal . Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation. . J. Biol. Chem. . 273 . 17 . 10784–91 . 1998 . 9553145 . 10.1074/jbc.273.17.10784 . free .
• Isaac C, Yang Y, Meier UT . Nopp140 functions as a molecular link between the nucleolus and the coiled bodies. . J. Cell Biol. . 142 . 2 . 319–29 . 1998 . 9679133 . 10.1083/jcb.142.2.319 . 2133063 .
• Blanchette P, Gilchrist CA, Baker RT, Gray DA . Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130. . Oncogene . 20 . 39 . 5533–7 . 2001 . 11571651 . 10.1038/sj.onc.1204823 . free .
• Chiu CM, Tsay YG, Chang CJ, Lee SC . Nopp140 is a mediator of the protein kinase A signaling pathway that activates the acute phase response alpha1-acid glycoprotein gene. . J. Biol. Chem. . 277 . 42 . 39102–11 . 2002 . 12167624 . 10.1074/jbc.M205915200 . free .
• Wang C, Query CC, Meier UT . Immunopurified small nucleolar ribonucleoprotein particles pseudouridylate rRNA independently of their association with phosphorylated Nopp140. . Mol. Cell. Biol. . 22 . 24 . 8457–66 . 2003 . 12446766 . 10.1128/MCB.22.24.8457-8466.2002 . 139890 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Brill LM, Salomon AR, Ficarro SB, etal . Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. . Anal. Chem. . 76 . 10 . 2763–72 . 2004 . 15144186 . 10.1021/ac035352d .
• Brandenberger R, Wei H, Zhang S, etal . Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. . Nat. Biotechnol. . 22 . 6 . 707–16 . 2005 . 15146197 . 10.1038/nbt971 . 27764390 .
• Beausoleil SA, Jedrychowski M, Schwartz D, etal . Large-scale characterization of HeLa cell nuclear phosphoproteins. . Proc. Natl. Acad. Sci. U.S.A. . 101 . 33 . 12130–5 . 2004 . 15302935 . 10.1073/pnas.0404720101 . 514446 . 2004PNAS..10112130B . free .

Notes and References

1. Pai CY, Chen HK, Sheu HL, Yeh NH . Cell-cycle-dependent alterations of a highly phosphorylated nucleolar protein p130 are associated with nucleologenesis . 108 . J Cell Sci . (Pt 5) . 1911–20 . Oct 1995 . 5 . 10.1242/jcs.108.5.1911 . 7657714 .
2. Chen HK, Pai CY, Huang JY, Yeh NH . Human Nopp140, which interacts with RNA polymerase I: implications for rRNA gene transcription and nucleolar structural organization . Mol Cell Biol . 19 . 12 . 8536–46 . Jan 2000 . 10567578 . 84972 . 10.1128/MCB.19.12.8536.
3. Web site: Entrez Gene: NOLC1 nucleolar and coiled-body phosphoprotein 1.
4. 10.1083/jcb.142.2.319 . Isaac . C . Yang Y . Meier U T . Jul 1998 . Nopp140 functions as a molecular link between the nucleolus and the coiled bodies . J. Cell Biol. . 142 . 2 . 319–29 . 0021-9525. 9679133 . 2133063 .
5. 10.1074/jbc.273.17.10784 . Miau . L H . Chang C J . Shen B J . Tsai W H . Lee S C . Apr 1998 . Identification of heterogeneous nuclear ribonucleoprotein K (hnRNP K) as a repressor of C/EBPbeta-mediated gene activation . J. Biol. Chem. . 273 . 17 . 10784–91 . 0021-9258. 9553145 . free .