Norgestomet Explained

Norgestomet, or norgestamet, sold under the brand name Syncro-Mate B and Crestar, is a progestin medication which is used in veterinary medicine to control estrus and ovulation in cattle.^{[1] [2]}

Uses

Veterinary

Norgestomet is used in veterinary medicine.

Pharmacology

Pharmacodynamics

Norgestomet is a progestogen. In addition to the progesterone receptor, it possesses weak (micromolar) affinity for the glucocorticoid receptor.^[3]

Chemistry

See also: List of progestogens, Progestogen ester and List of progestogen esters.

Norgestomet, also known as 11β-methyl-17α-acetoxy-19-norprogesterone or as 17α-hydroxy-11β-methyl-19-norpregn-4-ene-3,20-dione acetate, is a synthetic norpregnane steroid and a derivative of progesterone.

History

Norgestomet was developed and introduced for veterinary use in the mid-1970s.^[4]

Society and culture

Generic names

Norgestomet is the generic name of the drug and its,, and .^[5] It also known as norgestamet and is known by its developmental code name SC-21009.^[6]

Brand names

Norgestomet is marketed under the brand names Syncro-Mate B and Crestar.

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies . 14 November 2014. Springer. 978-1-4757-2085-3. 887–.
2. Book: Favero RJ, Henderson EA, Kesler DJ . The Ability of Norgesomet Impregnated Poly(dimethylsiloxane) to Maintain Pregnancy Subsequent to Ovarietomy. Gebelein CG, Dunn RL . Progress in Biomedical Polymers. https://books.google.com/books?id=-qXTBH9-an0C&pg=PA356 . 1 July 1990. Springer Science & Business Media. 978-0-306-43523-2. 356–.
3. Moffatt RJ, Zollers WG, Welshons WV, Kieborz KR, Garverick HA, Smith MF . Basis of norgestomet action as a progestogen in cattle . Domestic Animal Endocrinology . 10 . 1 . 21–30 . January 1993 . 8467644 . 10.1016/0739-7240(93)90005-v .
4. Book: Gordon U . Artificial Control O Oestrus and Ovulation . Controlled Breeding in Farm Animals. https://books.google.com/books?id=mEgvBQAAQBAJ&pg=PA40. 22 October 2013. Elsevier. 978-1-4832-8569-6. 40–.
5. Web site: Norgestomet . Drugs.com . https://web.archive.org/web/20180228100752/https://www.drugs.com/international/norgestomet.html . 28 February 2018 .
6. Web site: Effect of time of insemination and calf removal after estrus synchronization in beef cattle . 1979 . Houghton PL .