Norbudrine Explained

Class:	Sympathomimetic Bronchodilator
Cas Number:	15686-81-4
Cas Supplemental:	13329-35-6 (hydrochloride)
Pubchem:	166575
Chemspiderid:	145768
Unii:	8P6T83567P
Chembl:	2106796
Synonyms:	Norbutrine; RD-9338; N-Cyclobutylnoradrenaline; N-Cyclobutylnorepinephrine
Iupac Name:	4-[2-(cyclobutylamino)-1-hydroxyethyl]benzene-1,2-diol
C:	12
H:	17
N:	1
O:	3
Smiles:	C1CC(C1)NCC(C2=CC(=C(C=C2)O)O)O
Stdinchi:	1S/C12H17NO3/c14-10-5-4-8(6-11(10)15)12(16)7-13-9-2-1-3-9/h4-6,9,12-16H,1-3,7H2
Stdinchikey:	OVTZNVCECJYMDW-UHFFFAOYSA-N

Norbudrine (; developmental code name RD-9338), also known as norbutrine or as N-cyclobutylnoradrenaline, is a drug of the phenethylamine and catecholamine families described as a sympathomimetic and bronchodilator which was never marketed.^{[1] [2] [3]} It is the N-cyclobutyl analogue of norepinephrine (noradrenaline).^[4] The drug was first described in the literature by 1966.

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies . Springer US . 2014 . 978-1-4757-2085-3 . 17 October 2024 . 1-PA215.
2. Book: List PH, Hörhammer L . Chemikalien und Drogen Teil A: N-Q . Springer Berlin Heidelberg . Handbuch der Pharmazeutischen Praxis - Vollständige (4.) Neuausgabe . 2013 . 978-3-642-65035-2 . de . 17 October 2024 . 265–266.
3. Book: -drine sympathomimetics . The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances 2018 (Stem Book 2018) . https://cdn.who.int/media/docs/default-source/international-nonproprietary-names-(inn)/stembook-2018.pdf#page=95 . World Health Organization .
4. Web site: Norbudrine . PubChem . U.S. National Library of Medicine . 17 October 2024.