Nonsteroidal Explained

A nonsteroidal compound is a drug that is not a steroid nor a steroid derivative.^{[1] [2]} Nonsteroidal anti-inflammatory drugs (NSAIDs) are distinguished from corticosteroids as a class of anti-inflammatory agents.^[3]

List of nonsteroidal steroid receptor modulators

Examples include the following:

• Estrogens: benzestrol, bifluranol, estrobin (DBE), diethylstilbestrol (stilbestrol), dienestrol, erteberel, fosfestrol, hexestrol (dihydroxystilbestrol), methallenestril, methestrol, methestrol dipropionate, paroxypropione, prinaberel, and triphenylethylene, as well as many xenoestrogens
• : acolbifene, afimoxifene, arzoxifene, bazedoxifene, broparestrol, chlorotrianisene, clomifene, clomifenoxide, cyclofenil, droloxifene, enclomifene, endoxifen, ethamoxytriphetol, fispemifene, idoxifene, lasofoxifene, levormeloxifene, miproxifene, nafoxidine, nitromifene, ormeloxifene, ospemifene, panomifene, pipendoxifene, raloxifene, tamoxifen, toremifene, trioxifene, zindoxifene, zuclomifene
• Antiandrogens: apalutamide, bicalutamide, cimetidine, darolutamide, DIMP, enzalutamide, EPI-001, EPI-506, flutamide, hydroxyflutamide, inocoterone, inocoterone acetate, nilutamide, RU-58642, RU-58841, and topilutamide
• : AC-262,356, acetothiolutamide, andarine, BMS-564,929, enobosarm (ostarine), LGD-2226, LGD-3303, LGD-4033, S-23, and S-40503
• Aromatase inhibitors: anastrozole, aminoglutethimide, fadrozole, finrozole, letrozole, liarozole, norendoxifen, rogletimide (pyridoglutethimide), vorozole
• Other steroidogenesis inhibitors: aminoglutethimide, ketoconazole, orteronel, seviteronel, others
• Miscellaneous: tanaproget (progestogen), finerenone (antimineralocorticoid), esaxerenone (antimineralocorticoid), apararenone (antimineralocorticoid), AZD5423 (glucocorticoid), mapracorat

See also

• Nonsteroidal antiandrogen
• Nonsteroidal estrogen

Further reading

• Miquel JF, Gilbert J . A chemical classification of nonsteroidal antagonists of sex-steroid hormone action . J. Steroid Biochem. . 31 . 4B . 525–44 . 1988 . 10.1016/0022-4731(88)90004-0 . 3059055 .
• Buijsman. Rogier. Hermkens. Pedro. Rijn. Rachel. Stock. H.. Teerhuis. N.. Non-Steroidal Steroid Receptor Modulators. Current Medicinal Chemistry. 12. 9. 2005. 1017–1075. 0929-8673. 10.2174/0929867053764671. 16821162.
• Hermkens PH, Kamp S, Lusher S, Veeneman GH . Non-steroidal steroid receptor modulators . IDrugs . 9 . 7 . 488–94 . 2006 . 16821162 . 10.2174/0929867053764671.

Notes and References

1. Book: Edward J. Pavlik. Estrogens, Progestins, and Their Antagonists: Health Issues. 6 December 2012. Springer Science & Business Media. 978-1-4612-4096-9. 166–.
2. Book: Thomas Nogrady Professor of Medicinal Chemistry Concordia University (Emeritus). Donald F. Weaver Canada Research Chair and Professor of Medicine and Chemistry Dalhousie University. Medicinal Chemistry : A Molecular and Biochemical Approach: A Molecular and Biochemical Approach. 27 July 2005. Oxford University Press, USA. 978-0-19-802645-7. 322–.
3. Buer JK . Origins and impact of the term 'NSAID' . Inflammopharmacology . 22 . 5 . 263–7 . Oct 2014 . 25064056 . 10.1007/s10787-014-0211-2 . 10852/45403 . 16777111 . free .