Non-specific polyamine oxidase explained

Non-specific polyamine oxidase
Ec Number:	1.5.3.17

Non-specific polyamine oxidase (polyamine oxidase, Fms1, AtPAO3) is an enzyme with systematic name polyamine:oxygen oxidoreductase (3-aminopropanal or 3-acetamidopropanal-forming).^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

(1) spermine + O₂ + H₂O

\rightleftharpoons spermidine + 3-aminopropanal + H₂O₂

(2) spermidine + O₂ + H₂O

\rightleftharpoons putrescine + 3-aminopropanal + H₂O₂

(3) N¹-acetylspermine + O₂ + H₂O

\rightleftharpoons spermidine + 3-acetamidopropanal + H₂O₂

(4) N¹-acetylspermidine + O₂ + H₂O

\rightleftharpoons putrescine + 3-acetamidopropanal + H₂O₂

This enzyme is flavoprotein (FAD).

Notes and References

1. Moschou PN, Sanmartin M, Andriopoulou AH, Rojo E, Sanchez-Serrano JJ, Roubelakis-Angelakis KA . Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis . Plant Physiology . 147 . 4 . 1845–57 . August 2008 . 18583528 . 2492618 . 10.1104/pp.108.123802 .
2. Müller S, Walter RD . Purification and characterization of polyamine oxidase from Ascaris suum . The Biochemical Journal . 283 (Pt 1) . 75–80 . April 1992 . 1567380 . 1130995 .
3. Landry J, Sternglanz R . Yeast Fms1 is a FAD-utilizing polyamine oxidase . Biochemical and Biophysical Research Communications . 303 . 3 . 771–6 . April 2003 . 12670477 . 10.1016/s0006-291x(03)00416-9 .