Technetium (99mTc) nofetumomab merpentan explained

Technetium (99mTc) nofetumomab merpentan (trade name Verluma) is a mouse monoclonal antibody derivative used in the diagnosis of lung cancer,[1] gastrointestinal, breast, ovary, pancreas, kidney, cervix, and bladder carcinoma.[2] The antibody part, nofetumomab, is attached to the chelator merpentan, which links it to the radioisotope technetium-99m (99mTc).[3]

Nofetumomab

Nofetumomab is an antibody fragment that recognises the pancarcinoma glycoprotein antigen EpCAM.[4] and/or CD20/MS4A1[5]

It is the Fab part of murine MAb NR-LU-10.

Merpentan

The chelator part : merpentan is a phenthioate ligand, 2,3,5,6-tetrafluorophenyl-4,5-bis-5-[1-ethoxyethyl]-thioacetoamidopentanoate.[6]

Phenthioate

Phenthioate is an insecticide (Cidial) = O,o-dimethyl-S-(carbethoxy-phenylmethyl)dithiophosphate[7]

Notes and References

  1. Straka MR, Joyce JM, Myers DT . Tc-99m nofetumomab merpentan complements an equivocal bone scan for detecting skeletal metastatic disease from lung cancer . Clinical Nuclear Medicine . 25 . 1 . 54–5 . January 2000 . 10634533 . 10.1097/00003072-200001000-00013 .
  2. Breitz HB, Tyler A, Bjorn MJ, Lesley T, Weiden PL . Clinical experience with Tc-99m nofetumomab merpentan (Verluma) radioimmunoscintigraphy . Clinical Nuclear Medicine . 22 . 9 . 615–20 . September 1997 . 9298295 . 10.1097/00003072-199709000-00007 .
  3. Web site: International Nonproprietary Names (INN) for pharmaceutical substances . https://web.archive.org/web/20110703193226/http://apps.who.int/medicinedocs/pdf/s4894e/s4894e.pdf . dead . July 3, 2011 . 2002 . World Health Organization . Geneva .
  4. Book: Tsurushita N, Vasquez M . Humanization of monoclonal antibodies . Reth M, Radbruch A, Alt F, Honjo T, Neuberger M . Molecular Biology of B Cells . January 2004 . 533–545 . Academic Press . https://books.google.com/books?id=fF8d3eZ6SZ8C&pg=PA533 . 978-0-08-047950-7 .
  5. Web site: Anti-MS4A1 Therapeutic Antibody (Technetium (99MTC) Nofetumomab Merpentan) . Creative BioLabs .
  6. Web site: Efrain . Mudd . vanc . 27 February 2015 . Monoclonal Antibody Radionuclide Test Kits . Pharmacological Sciences .
  7. US . 3934010 . Insecticidal composition and method utilizing phosphoric acid phenylsulphonamide esters . Drabek J, Varsanyi D . Ciba Geigy Corporation . 20 January 1976 .

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