Nobiletin Explained

Nobiletin is a flavonoid isolated from citrus peels. It is an O-methylated flavone that has the activity to rescue bulbectomy-induced memory impairment.^[1]

Potential pharmacology

Nobiletin was found to potentially inhibit cartilage degradation.^[2]

Nobiletin was shown to augment AMPA receptor activity and long-term potentiation in cell culture.^[3] Synergistic chemopreventive effects of nobiletin and atorvastatin on colon carcinogenesis have been described.^[4] Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer[5].

References

[5] Kim E, Kim YJ, Ji Z, Kang JM, Wirianto M, Paudel KR, Smith JA, Ono K, Kim JA, Eckel-Mahan K, Zhou X. ROR activation by Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer. Cell death & disease. 2022 Apr 19;13(4):374.

External links

• Nobiletin, phytochemicals.info

Notes and References

1. Nagase H, Yamakuni T, Matsuzaki K, Maruyama Y, Kasahara J, Hinohara Y, Kondo S, Mimaki Y, Sashida Y, Tank AW, Fukunaga K, Ohizumi Y . 2005 . Mechanism of Neurotrophic Action of Nobiletin in PC12D Cells . Biochemistry . 44 . 42 . 13683–13691 . 0006-2960 . 10.1021/bi050643x . 16229458 . Nobiletin is a nonpeptide compound with a low molecular weight from a citrus fruit and has the activity to rescue bulbectomy-induced memory impairment .
2. Y.. Henrotin. C. Lambert . D. Couchourel . C. Ripoll . E. Chiotelli . January 2011. Nutraceuticals: do they represent a new era in the management of osteoarthritis? – a narrative review from the lessons taken with five products. Osteoarthritis and Cartilage. 19. 1. 1–21. 10.1016/j.joca.2010.10.017. 21035558. 2011-12-27. free.
3. Eur J Pharmacol . 2008 . 578 . 2–3 . 194–200 . Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1, and the postsynaptic receptor response to glutamate in murine hippocampus . Matsuzaki K, Miyazaki K, Sakai S, Yawo H, Nakata N, Moriguchi S, Fukunaga K, Yokosuka A, Sashida Y, Mimaki Y, Yamakuni T, Ohizumi Y . 17976577 . 10.1016/j.ejphar.2007.09.028.
4. Wu. Xian. Song. Mingyue. Qiu. Peiju. Rakariyatham. Kanyasiri. Li. Fang. Gao. Zili. Cai. Xiaokun. Wang. Minqi. Xu. Fei. Zheng. Jinkai. Xiao. Hang. Synergistic chemopreventive effects of nobiletin and atorvastatin on colon carcinogenesis. Carcinogenesis. 1 April 2017. 38. 4. 455–464. 10.1093/carcin/bgx018. 28207072. 6248647. en. 0143-3334.