Nizatidine Explained

Nizatidine is a histamine H2 receptor antagonist that inhibits stomach acid production, and is commonly used in the treatment of peptic ulcer disease and gastroesophageal reflux disease.[1]

It was patented in 1980 and approved for medical use in 1988.[2] [3] It was developed by Eli Lilly.

Medical use

See main article: H2 antagonist. Nizatidine is used to treat duodenal ulcers, gastric ulcers, and gastroesophageal reflux disease (GERD/GORD), and to prevent stress ulcers.[4]

Adverse effects

Side effects are uncommon, usually minor, and include diarrhea, constipation, fatigue, drowsiness, headache, and muscle aches.[4]

History and development

Nizatidine was developed by Eli Lilly, and was first marketed in 1988. It is considered to be equipotent with ranitidine and differs by the substitution of a thiazole ring in place of the furan ring in ranitidine. In September 2000, Eli Lilly announced they would sell the sales and marketing rights for Axid to Reliant Pharmaceuticals.[5] Subsequently, Reliant developed the oral solution of Axid, marketing this in 2004, after gaining approval from the U.S. Food and Drug Administration (FDA).[6] However, a year later, they sold rights of the Axid Oral Solution (including the issued patent[7] protecting the product) to Braintree Laboratories.[8]

Society and culture

Brand names

Brand names include Tazac and Axid.

Notes and References

  1. Romero M, Franzosi MG . [Nizatidine] . it . Medicina . 9 . 1 . 93–96 . 1989 . 2567957 .
  2. Web site: Nizatidine: FDA-Approved Drugs . U.S. Food and Drug Administration (FDA) . 20 March 2020.
  3. Book: Fischer J, Ganellin CR . Analogue-based Drug Discovery . 2006 . John Wiley & Sons . 9783527607495 . 44 . en.
  4. Book: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury . Nizatidine . NCBI Bookshelf . 25 January 2018 . 31643707 . https://www.ncbi.nlm.nih.gov/books/NBK548387/ . 19 March 2020 . NBK548387 .
  5. Encyclopedia: Eli Lilly and Company and Reliant Pharmaceuticals Announce Agreement for U.S. Sales and Marketing Rights to Axid(R) . 7 September 2000 . https://web.archive.org/web/20080526223021/http://www.encyclopedia.com/doc/1G1-65062714.html?Q=%22axid%22 . May 26, 2008 . Encyclopedia.com .
  6. Web site: Reliant Pharmaceuticals to Launch AxidŽ Oral Solution . 26 July 2004 . Reliant Pharmaceuticals, LLC .
  7. US . 6930119 . Liquid pharmaceutical composition . Bobotas G, Fawzy AA . Reliant Pharmaceuticals, LLC . 24 June 2005 .
  8. Web site: Reliant Pharmaceuticals Announces the Sale of Axid® Oral Solution to Braintree Laboratories . https://web.archive.org/web/20070814071007/http://www.reliantrx.com/investor/press_releases/063005.htm . August 14, 2007 . Reliant Pharmaceuticals, LLC .

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