Nitroquinoline-N-oxide reductase explained

nitroquinoline-N-oxide reductase
Ec Number:	1.7.1.9
Cas Number:	37256-35-2
Go Code:	0050465

In enzymology, a nitroquinoline-N-oxide reductase is an enzyme that catalyzes the chemical reaction

4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H₂O

\rightleftharpoons 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H⁺

The 4 substrates of this enzyme are 4-hydroxyaminoquinoline N-oxide, NAD⁺, NADP⁺, and H₂O, whereas its 4 products are 4-nitroquinoline N-oxide, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-(hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase. Other names in common use include 4-nitroquinoline 1-oxide reductase, 4NQO reductase, and NAD(P)H2:4-nitroquinoline-N-oxide oxidoreductase.

References

• Toriyama N . 1965 . [Metabolism of quinoline derivatives. On the reducing enzyme of 4-nitroquinoline-N-oxide] . Nichidai Igaku Zasshi . 24 . 423 - 432 .
• Stanley JS, York JL, Benson AM . 1992 . Nitroreductases and glutathione transferases that act on 4-nitroquinoline 1-oxide and their differential induction by butylated hydroxyanisole in mice . Cancer Res. . 52 . 58 - 63 . 1370076 . 1 .