Nitric oxide reductase (NAD(P), nitrous oxide-forming) explained

Nitric oxide reductase (NAD(P), nitrous oxide-forming)
Ec Number:	1.7.1.14

Nitric oxide reductase (NAD(P), nitrous oxide-forming) (fungal nitric oxide reductase, cytochrome P450nor, NOR (ambiguous)) is an enzyme with systematic name nitrous oxide:NAD(P) oxidoreductase.^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction

N₂O + NAD(P)⁺ +

\rightleftharpoons 2 NO + NAD(P)H + H⁺

This enzyme is heme-thiolate protein (P450).

Notes and References

1. Shoun H, Tanimoto T . Denitrification by the fungus Fusarium oxysporum and involvement of cytochrome P-450 in the respiratory nitrite reduction . The Journal of Biological Chemistry . 266 . 17 . 11078–82 . June 1991 . 2040619 .
2. Shiro Y, Fujii M, Iizuka T, Adachi S, Tsukamoto K, Nakahara K, Shoun H . Spectroscopic and kinetic studies on reaction of cytochrome P450nor with nitric oxide. Implication for its nitric oxide reduction mechanism . The Journal of Biological Chemistry . 270 . 4 . 1617–23 . January 1995 . 7829493 .
3. Zhang L, Kudo T, Takaya N, Shoun H . The B' helix determines cytochrome P450nor specificity for the electron donors NADH and NADPH . The Journal of Biological Chemistry . 277 . 37 . 33842–7 . September 2002 . 12105197 . 10.1074/jbc.M203923200 . free .
4. Oshima R, Fushinobu S, Su F, Zhang L, Takaya N, Shoun H . Structural evidence for direct hydride transfer from NADH to cytochrome P450nor . Journal of Molecular Biology . 342 . 1 . 207–17 . September 2004 . 15313618 . 10.1016/j.jmb.2004.07.009 .