Niperotidine Explained

Niperotidine is a histamine antagonist selective for the H2 subtype. It was studied as a treatment for excessive gastric acidity,[1] but withdrawn after human trials showed liver damage.[2]

Notes and References

  1. 1983712. 1990. Palasciano. G. The effect of the H2-antagonist niperotidine on intragastric acidity in healthy subjects undergoing 24-hour pH-monitoring. The Italian Journal of Gastroenterology. 22. 5. 291–4. Maggi. V. Portincasa. P.
  2. 9314138. 1997. Gasbarrini. G. Acute liver injury related to the use of niperotidine. Journal of Hepatology. 27. 3. 583–6. Gentiloni. N. Febbraro. S. Gasbarrini. A. Di Campli. C. Cesana. M. Miglio. F. Miglioli. M. Ghinelli. F. d'Ambrosi. A. Amoroso. P. Pacini. F. Salvadori. G. 10.1016/s0168-8278(97)80365-0.

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