Nilestriol Explained

Nilestriol (brand name Wei Ni An; developmental code name LY-49825), also known as nylestriol, is a synthetic estrogen which was patented in 1971^[1] and is marketed in China.^{[2] [3]} It is the 3-cyclopentyl ether of ethinylestriol, and is also known as ethinylestriol cyclopentyl ether (EE3CPE).^[4] Nilestriol is a prodrug of ethinylestriol, and is a more potent estrogen in comparison. It is described as a slowly-metabolized, long-acting estrogen and derivative of estriol.^{[5] [6]} Nilestriol was assessed in combination with levonorgestrel for the potential treatment of postmenopausal osteoporosis, but this formulation ultimately was not marketed.^[7]

See also

• List of estrogen esters § Ethers of steroidal estrogens

Notes and References

1. Book: Official Gazette of the United States Patent and Trademark Office: Patents. 1975. U.S. Department of Commerce, Patent and Trademark Office. 1677.
2. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 891–.
3. Web site: Nilestriol . Drugs.com .
4. Book: McGuire, William . vanc . Experimental Biology. 14 December 2013. Springer Science & Business Media. 978-1-4757-4673-0. 161–.
5. Schoenberg DR . Ph.D. . Biochemical Properties of the Cytoplasmic Estrogen Receptors from Immature Rat and Mature Rabbit Uteri. 1977. University of Wisconsin. A-17.
6. Book: Excerpta Medica . Section 10: Obstetrics and gynecology. https://books.google.com/books?id=55-aAAAAIAAJ . 1978 .
7. Book: Aronson JK . Meyler's Side Effects of Endocrine and Metabolic Drugs. 21 February 2009. Elsevier. 978-0-08-093292-7. 173–.