Niflumic acid explained

Niflumic acid is a drug used for joint and muscular pain. It is categorized as an inhibitor of cyclooxygenase-2. In experimental biology, it has been employed to inhibit chloride channels.^[1] It has also been reported to act on GABA-A^[2] and NMDA channels^[3] and to block T-type calcium channels.^[4]

Notes and References

1. Knauf PA, Mann NA . Use of niflumic acid to determine the nature of the asymmetry of the human erythrocyte anion exchange system . The Journal of General Physiology . 83 . 5 . 703–25 . May 1984 . 6736917 . 2215658 . 10.1085/jgp.83.5.703 .
2. Sinkkonen ST, Mansikkamäki S, Möykkynen T, Lüddens H, Uusi-Oukari M, Korpi ER . Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug . Molecular Pharmacology . 64 . 3 . 753–63 . September 2003 . 12920213 . 10.1124/mol.64.3.753 .
3. Lerma J, Martín del Río R . Chloride transport blockers prevent N-methyl-D-aspartate receptor-channel complex activation . Molecular Pharmacology . 41 . 2 . 217–22 . February 1992 . 1371581 .
4. Balderas E, Ateaga-Tlecuitl R, Rivera M, Gomora JC, Darszon A . Niflumic acid blocks native and recombinant T-type channels . Journal of Cellular Physiology . 227 . 6 . 2542–55 . June 2012 . 21898399 . 4146346 . 10.1002/jcp.22992 .