Nifenazone Explained
Nifenazone is a drug that has been used as an analgesic for a number of rheumatic conditions.[1]
Synthesis
Nifenazone is the amide formed when ampyrone and the acid chloride of nicotinic acid are combined in a Schotten–Baumann reaction.[2] [3]
See also
Notes and References
- Hart FD, Boardman PL . British Medical Journal . 1 . 5397 . 1553–4 . June 1964 . 14133613 . 1814611 . 10.1136/bmj.1.5397.1553 . Trial of Nifenazone ("Thylin") .
- 10.1007/BF00901766 . Über neue pharmakologisch wirksame Amide und Ester der Nicotinsäure . 1957 . Pongratz A, Zirm L . Monatshefte für Chemie . 88 . 3 . 330–335 .
- Web site: Nifenazone . Pharmaceutical Substances . Georg Thieme Verlag KG . 2024-07-16 .