Nicotine dehydrogenase explained
| nicotine dehydrogenase |
| Ec Number: | 1.5.99.4 |
| Cas Number: | 37256-31-8 |
| Go Code: | 0018535 |
In enzymology, a nicotine dehydrogenase is an enzyme that catalyzes the chemical reaction
(S)-nicotine + acceptor + H2O
(S)-6-hydroxynicotine + reduced acceptor
The 3 substrates of this enzyme are (S)-nicotine, acceptor, and H2O, whereas its two products are (S)-6-hydroxynicotine and reduced acceptor.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with other acceptors. The systematic name of this enzyme class is nicotine:acceptor 6-oxidoreductase (hydroxylating). Other names in common use include nicotine oxidase, D-nicotine oxidase, nicotine:(acceptor) 6-oxidoreductase (hydroxylating), and L-nicotine oxidase. It has 2 cofactors: metal, and FMN.
References
- BEHRMAN EJ, STANIER RY . 1957 . The bacterial oxidation of nicotinic acid . J. Biol. Chem. . 228 . 923 - 45 . 13475371 . 2 .
- Decker K, Bleeg H . 1965 . Induction and purification of stereospecific nicotine oxidizing enzymes from Arthrobacter oxidans . Biochim. Biophys. Acta . 105 . 313 - 24 . 5849820 . 2 . 10.1016/s0926-6593(65)80155-2.
- Hochstein LI, Dalton BP . 1967 . The purification and properties of nicotine oxidase . Biochim. Biophys. Acta . 139 . 56 - 68 . 4962139 . 1 . 10.1016/0005-2744(67)90113-1.
- HOCHSTEIN LI, RITTENBERG SC . 1959 . The bacterial oxidation of nicotine. II. The isolation of the first oxidative product and its identification as (1)-6-hydroxynicotine . J. Biol. Chem. . 234 . 156 - 60 . 13610912 . 1 .
