Nicotine blue oxidoreductase explained

Nicotine blue oxidoreductase
Ec Number:	1.1.1.328

Nicotine blue oxidoreductase (nboR (gene)) is an enzyme with systematic name 3,3'-bipyridine-2,2',5,5',6,6'-hexol:NADP⁺ 11-oxidoreductase.^[1] This enzyme catalyses the following chemical reaction

3,3'-bipyridine-2,2',5,5',6,6'-hexol + NAD(P)⁺

\rightleftharpoons

(E)-2,2',5,5'-tetrahydroxy-6H,6'H-[3,3'-bipyridinylidene]-6,6'-dione + NAD(P)H + H⁺

This enzyme is extracted from bacterium Arthrobacter nicotinovorans.

Notes and References

Mihasan M, Chiribau CB, Friedrich T, Artenie V, Brandsch R . An NAD(P)H-nicotine blue oxidoreductase is part of the nicotine regulon and may protect Arthrobacter nicotinovorans from oxidative stress during nicotine catabolism . Applied and Environmental Microbiology . 73 . 8 . 2479–85 . April 2007 . 17293530 . 1855579 . 10.1128/AEM.02668-06 .