Nicotinate riboside kinase explained

Nicotinate riboside kinase
Ec Number:	2.7.1.173

Nicotinate riboside kinase (ribosylnicotinic acid kinase, nicotinic acid riboside kinase, NRK1) is an enzyme with systematic name ATP:beta-D-ribosylnicotinate 5-phosphotransferase.^[1] This enzyme catalyses the following chemical reaction

ATP + beta-D-ribosylnicotinate

\rightleftharpoons ADP + nicotinate beta-D-ribonucleotide

The enzyme from yeast and human also acts as EC 2.7.1.22 (ribosylnicotinamide kinase).

Notes and References

1. Tempel W, Rabeh WM, Bogan KL, Belenky P, Wojcik M, Seidle HF, Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C . Nicotinamide riboside kinase structures reveal new pathways to NAD+ . PLOS Biology . 5 . 10 . e263 . October 2007 . 17914902 . 1994991 . 10.1371/journal.pbio.0050263 . free .