Nicotinate dehydrogenase (cytochrome) explained

Nicotinate dehydrogenase (cytochrome)
Ec Number:	1.17.2.1

Nicotinate dehydrogenase (cytochrome) (nicotinic acid hydroxylase, nicotinate hydroxylase) is an enzyme with systematic name nicotinate:cytochrome 6-oxidoreductase (hydroxylating).^{[1] [2]} This enzyme catalyses the following chemical reaction

nicotinate + a ferricytochrome + H₂O

\rightleftharpoons 6-hydroxynicotinate + a ferrocytochrome + 2 H⁺

This two-component enzyme from Pseudomonas belongs to the family of xanthine dehydrogenases.

See also

• Nicotinate dehydrogenase

Notes and References

1. Jiménez JI, Canales A, Jiménez-Barbero J, Ginalski K, Rychlewski L, García JL, Díaz E . Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440 . Proceedings of the National Academy of Sciences of the United States of America . 105 . 32 . 11329–34 . August 2008 . 18678916 . 2516282 . 10.1073/pnas.0802273105 . free .
2. Yang Y, Yuan S, Chen T, Ma P, Shang G, Dai Y . Cloning, heterologous expression, and functional characterization of the nicotinate dehydrogenase gene from Pseudomonas putida KT2440 . Biodegradation . 20 . 4 . 541–9 . July 2009 . 19118407 . 10.1007/s10532-008-9243-x . 23219659 .