Nicotinamide-nucleotide amidase explained

nicotinamide-nucleotide amidase
Ec Number:3.5.1.42
Cas Number:37355-58-1
Go Code:0019159

In enzymology, a nicotinamide-nucleotide amidase is an enzyme that catalyzes the chemical reaction

beta-nicotinamide D-ribonucleotide + H2O

\rightleftharpoons

beta-nicotinate D-ribonucleotide + NH3

Thus, the two substrates of this enzyme are beta-nicotinamide D-ribonucleotide and H2O, whereas its two products are beta-nicotinate D-ribonucleotide and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is nicotinamide-D-ribonucleotide amidohydrolase. Other names in common use include NMN deamidase, nicotinamide mononucleotide deamidase, and nicotinamide mononucleotide amidohydrolase. This enzyme participates in nicotinate and nicotinamide metabolism.

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