Neuropeptide Y receptor Y2 explained

Neuropeptide Y receptor type 2 (Y2R) is a member of the neuropeptide Y receptor family of G-protein coupled receptors, that in humans is encoded by the NPY2R gene.^{[1] [2]}

Selective ligands

Agonists

• Neuropeptide Y (endogenous agonist, non subtype selective)
• Neuropeptide Y fragment 13-36 (NPY₂ selective agonist)
• Peptide YY
• Peptide YY 3-36 fragment^[3]

Antagonists

• BIIE-0246 (CAS# 246146-55-4)
• JNJ 5207787 (CAS# 683746-68-1)
• SF 11 (CAS# 443292-81-7)

See also

• Neuropeptide Y receptor

External links

• Web site: Neuropeptide Y Receptors: Y₂ . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-09 . 2016-03-03 . https://web.archive.org/web/20160303165745/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2368 . dead .

Further reading

• Wan CP, Lau BH . Neuropeptide Y receptor subtypes . Life Sciences . 56 . 13 . 1055–64 . Feb 1995 . 9001438 . 10.1016/0024-3205(95)00041-4 .
• Parker E, Van Heek M, Stamford A . Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status . European Journal of Pharmacology . 440 . 2–3 . 173–87 . Apr 2002 . 12007534 . 10.1016/S0014-2999(02)01427-9 .
• Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA . Cloned human neuropeptide Y receptor couples to two different second messenger systems . Proceedings of the National Academy of Sciences of the United States of America . 89 . 13 . 5794–8 . Jul 1992 . 1321422 . 402104 . 10.1073/pnas.89.13.5794 . 1992PNAS...89.5794H . free .
• Gerald C, Walker MW, Vaysse PJ, He C, Branchek TA, Weinshank RL . Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype . The Journal of Biological Chemistry . 270 . 45 . 26758–61 . Nov 1995 . 7592910 . 10.1074/jbc.270.45.26758 . free .
• Lynch JW, Lemos VS, Bucher B, Stoclet JC, Takeda K . A pertussis toxin-insensitive calcium influx mediated by neuropeptide Y2 receptors in a human neuroblastoma cell line . The Journal of Biological Chemistry . 269 . 11 . 8226–33 . Mar 1994 . 10.1016/S0021-9258(17)37183-1 . 8132547 . free .
• Gehlert DR, Beavers LS, Johnson D, Gackenheimer SL, Schober DA, Gadski RA . Expression cloning of a human brain neuropeptide Y Y2 receptor . Molecular Pharmacology . 49 . 2 . 224–8 . Feb 1996 . 8632753 .
• Yan H, Yang J, Marasco J, Yamaguchi K, Brenner S, Collins F, Karbon W . Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors . Proceedings of the National Academy of Sciences of the United States of America . 93 . 10 . 4661–5 . May 1996 . 8643460 . 39335 . 10.1073/pnas.93.10.4661 . free . 1996PNAS...93.4661Y .
• Ammar DA, Eadie DM, Wong DJ, Ma YY, Kolakowski LF, Yang-Feng TL, Thompson DA . Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene . Genomics . 38 . 3 . 392–8 . Dec 1996 . 8975716 . 10.1006/geno.1996.0642 . Kolakowski . free .
• Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP . GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain . The Journal of Biological Chemistry . 273 . 28 . 17749–55 . Jul 1998 . 9651375 . 10.1074/jbc.273.28.17749 . free .
• Caberlotto L, Fuxe K, Rimland JM, Sedvall G, Hurd YL . Regional distribution of neuropeptide Y Y2 receptor messenger RNA in the human post mortem brain . Neuroscience . 86 . 1 . 167–78 . Sep 1998 . 9692752 . 10.1016/S0306-4522(98)00039-6 . 45849983 .
• Goumain M, Voisin T, Lorinet AM, Ducroc R, Tsocas A, Rozé C, Rouet-Benzineb P, Herzog H, Balasubramaniam A, Laburthe M . The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning . Molecular Pharmacology . 60 . 1 . 124–34 . Jul 2001 . 11408607 . 10.1124/mol.60.1.124. 11573265 .
• Cox HM, Tough IR . Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa . British Journal of Pharmacology . 135 . 6 . 1505–12 . Mar 2002 . 11906964 . 1573267 . 10.1038/sj.bjp.0704604 .
• Uddman R, Möller S, Nilsson T, Nyström S, Ekstrand J, Edvinsson L . Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues . Peptides . 23 . 5 . 927–34 . May 2002 . 12084524 . 10.1016/S0196-9781(02)00003-7 . 31244551 .
• Hyland NP, Sjöberg F, Tough IR, Herzog H, Cox HM . Functional consequences of neuropeptide Y Y 2 receptor knockout and Y2 antagonism in mouse and human colonic tissues . British Journal of Pharmacology . 139 . 4 . 863–71 . Jun 2003 . 12813010 . 1573894 . 10.1038/sj.bjp.0705298 .
• Hung CC, Pirie F, Luan J, Lank E, Motala A, Yeo GS, Keogh JM, Wareham NJ, O'Rahilly S, Farooqi IS . Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits . Diabetes . 53 . 9 . 2461–6 . Sep 2004 . 15331560 . 10.2337/diabetes.53.9.2461 . free .
• Tang T, Hartig C, Chen Q, Zhao W, Kaiser A, Zhang X, Zhang H, Qu H, Yi C, Ma L, Han S, Zhao Q, Beck-Sickinger AG, Wu B . Structural basis for ligand recognition of the neuropeptide Y Y2 receptor . Nature Communications . Feb 2021 . 12 . 1 . 737 . 33531491 . 7854658. 10.1038/s41467-021-21030-9 . free .

Notes and References

1. Rose PM, Fernandes P, Lynch JS, Frazier ST, Fisher SM, Kodukula K, Kienzle B, Seethala R . Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor . The Journal of Biological Chemistry . 270 . 39 . 22661–4 . Sep 1995 . 7559383 . 10.1074/jbc.270.39.22661 . free .
2. Web site: Entrez Gene: NPY2R neuropeptide Y receptor Y2.
3. Murphy KG, Dhillo WS, Bloom SR . Gut peptides in the regulation of food intake and energy homeostasis . Endocrine Reviews . 27 . 7 . 719–27 . Dec 2006 . 17077190 . 10.1210/er.2006-0028 . 24899878 .