Neuropeptide Y receptor explained
| neuropeptide Y receptor Y1 |
| Hgncid: | 7956 |
| Symbol: | NPY1R |
| Altsymbols: | NPYR |
| Entrezgene: | 4886 |
| Omim: | 162641 |
| Refseq: | NM_000909 |
| Uniprot: | P25929 |
| Chromosome: | 4 |
| Arm: | q |
| Band: | 31.3 |
| Locussupplementarydata: | -q32 |
| neuropeptide Y receptor Y5 |
| Hgncid: | 7958 |
| Symbol: | NPY5R |
| Entrezgene: | 4889 |
| Omim: | 602001 |
| Refseq: | NM_006174 |
| Uniprot: | Q15761 |
| Chromosome: | 4 |
| Arm: | q |
| Band: | 31 |
| Locussupplementarydata: | -q32 |
Neuropeptide Y receptors are a family of receptors belonging to class A G-protein coupled receptors and they are activated by the closely related peptide hormones neuropeptide Y, peptide YY and pancreatic polypeptide.[1] These receptors are involved in the control of a diverse set of behavioral processes including appetite, circadian rhythm, and anxiety.[2] [3] [4] [5] [6] [7]
Activated neuropeptide receptors release the Gi subunit from the heterotrimeric G protein complex. The Gi subunit in turn inhibits the production of the second messenger cAMP from ATP.
Only the crystal structure of Y1 in complex with two antagonist is available.[8]
Types
There are five known mammalian neuropeptide Y receptors designated Y1 through Y5.[9] Four neuropeptide Y receptors each encoded by a different gene have been identified in humans, all of which may represent therapeutic targets for obesity and other disorders.[10] [11] [12]
Antagonists
External links
- Web site: Neuropeptide Y Receptors . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2007-10-25 . 2016-03-03 . https://web.archive.org/web/20160303193341/http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1292 . dead .
Notes and References
- Michel MC, Beck-Sickinger A, Cox H, Doods HN, Herzog H, Larhammar D, Quirion R, Schwartz T, Westfall T . XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors . Pharmacol. Rev. . 50 . 1 . 143–50 . March 1998 . 9549761 .
- Heilig M . The NPY system in stress, anxiety and depression . Neuropeptides . 38 . 4 . 213–24 . August 2004 . 15337373 . 10.1016/j.npep.2004.05.002 . 37034137 .
- Harro J . CCK and NPY as anti-anxiety treatment targets: promises, pitfalls, and strategies . Amino Acids . 31 . 3 . 215–30 . October 2006 . 16738800 . 10.1007/s00726-006-0334-x . 2017793 .
- Eaton K, Sallee FR, Sah R . Relevance of neuropeptide Y (NPY) in psychiatry . Current Topics in Medicinal Chemistry . 7 . 17 . 1645–59 . 2007 . 17979774 . 10.2174/156802607782341037 .
- Xapelli S, Agasse F, Ferreira R, Silva AP, Malva JO . Neuropeptide Y as an endogenous antiepileptic, neuroprotective and pro-neurogenic peptide . Recent Patents on CNS Drug Discovery . 1 . 3 . 315–24 . November 2006 . 18221213 . 10.2174/157488906778773689 .
- Vona-Davis LC, McFadden DW . NPY family of hormones: clinical relevance and potential use in gastrointestinal disease . Current Topics in Medicinal Chemistry . 7 . 17 . 1710–20 . 2007 . 17979780 . 10.2174/156802607782340966 .
- Lindner D, Stichel J, Beck-Sickinger AG . Molecular recognition of the NPY hormone family by their receptors . Nutrition (Burbank, Los Angeles County, Calif.) . 24 . 9 . 907–17 . September 2008 . 18725086 . 10.1016/j.nut.2008.06.025 .
- Yang Z, Han S, Keller M, Kaiser A, Bender BJ, Bosse M, Burkert K, Kögler LM, Wifling D, Bernhardt G, Plank N, Littmann T, Schmidt P, Yi C, Li B, Ye S, Zhang R, Xu B, Larhammar D, Stevens RC, Huster D, Meiler J, Zhao Q, Beck-Sickinger AG, Buschauer A, Wu B . 1 receptor . Nature . 556 . 7702 . 520–524 . April 2018 . 29670288 . 5920736 . 10.1038/s41586-018-0046-x .
- Larhammar D, Salaneck E . Molecular evolution of NPY receptor subtypes . Neuropeptides . 38 . 4 . 141–51 . 2004 . 15337367 . 10.1016/j.npep.2004.06.002 . 43696257 .
- Kamiji MM, Inui A . Neuropeptide y receptor selective ligands in the treatment of obesity . Endocrine Reviews . 28 . 6 . 664–84 . October 2007 . 17785427 . 10.1210/er.2007-0003 . free .
- MacNeil DJ . NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs . Current Topics in Medicinal Chemistry . 7 . 17 . 1721–33 . 2007 . 17979781 . 10.2174/156802607782341028 .
- Kamiji MM, Inui A . NPY Y2 and Y4 receptors selective ligands: promising anti-obesity drugs? . Current Topics in Medicinal Chemistry . 7 . 17 . 1734–42 . 2007 . 17979782 . 10.2174/156802607782340957 .
