Neuromedin S Explained

Neuromedin S
Hgncid:	32203
Symbol:	NMS
Entrezgene:	129521
Chromosome:	2
Arm:	q
Band:	11.2

Neuromedin S is a 36-amino acid neuropeptide found in the brain of humans and other mammals. It is produced in the suprachiasmatic nucleus of the hypothalamus and is related to neuromedin U. It is thought to be involved in regulation of circadian rhythm and also has appetite suppressant effects,^{[1] [2] [3] [4] [5]} as well as regulating the release of several other peptide hormones including vasopressin,^[6] luteinizing hormone,^[7] and oxytocin.^[8]

See also

• Neuromedin U receptor

Notes and References

1. Mori K, Miyazato M, Ida T, Murakami N, Serino R, Ueta Y, Kojima M, Kangawa K . Identification of neuromedin S and its possible role in the mammalian circadian oscillator system . The EMBO Journal . 24 . 2 . 325–35 . January 2005 . 15635449 . 545815 . 10.1038/sj.emboj.7600526 .
2. Book: Mori K, Miyazato M, Kangawa K . Orphan G Protein-Coupled Receptors and Novel Neuropeptides . Neuromedin S: Discovery and Functions . Results and Problems in Cell Differentiation . 46 . 201–12 . 2008 . 18214396 . 10.1007/400_2007_054 . 978-3-540-78350-3 .
3. Novak CM . Neuromedin S and U . Endocrinology . 150 . 7 . 2985–7 . July 2009 . 19549882 . 10.1210/en.2009-0448 . 2703548.
4. Peier A, Kosinski J, Cox-York K, Qian Y, Desai K, Feng Y, Trivedi P, Hastings N, Marsh DJ . The antiobesity effects of centrally administered neuromedin U and neuromedin S are mediated predominantly by the neuromedin U receptor 2 (NMUR2) . Endocrinology . 150 . 7 . 3101–9 . July 2009 . 19324999 . 10.1210/en.2008-1772 . 2703546.
5. Mitchell J, Maguire J, Davenport A . Emerging pharmacology and physiology of neuromedin U and the structurally related peptide neuromedin S . . 158. 1. 87–103. June 2009 . 19519756 . 10.1111/j.1476-5381.2009.00252.x . 2795236.
6. Sakamoto T, Mori K, Nakahara K, Miyazato M, Kangawa K, Sameshima H, Murakami N . Neuromedin S exerts an antidiuretic action in rats . Biochemical and Biophysical Research Communications . 361 . 2 . 457–61 . September 2007 . 17645872 . 10.1016/j.bbrc.2007.07.036 .
7. Vigo E, Roa J, López M, Castellano JM, Fernandez-Fernandez R, Navarro VM, Pineda R, Aguilar E, Diéguez C, Pinilla L, Tena-Sempere M . Neuromedin s as novel putative regulator of luteinizing hormone secretion . Endocrinology . 148 . 2 . 813–23 . February 2007 . 17110433 . 10.1210/en.2006-0636 . free .
8. Sakamoto T, Mori K, Miyazato M, Kangawa K, Sameshima H, Nakahara K, Murakami N . Involvement of neuromedin S in the oxytocin release response to suckling stimulus . Biochemical and Biophysical Research Communications . 375 . 1 . 49–53 . October 2008 . 18675786 . 10.1016/j.bbrc.2008.07.124 .