Neurolysin Explained

Neurolysin
Ec Number:3.4.24.16
Cas Number:149371-24-4

Neurolysin (neurotensin endopeptidase, endopeptidase 24.16, endo-oligopeptidase B (proline-endopeptidase)) is an enzyme.[1] [2] [3] This enzyme catalyses the following chemical reaction

Preferential cleavage in neurotensin: Pro10-Tyr

This enzyme belongs to the peptidase family M3.

Notes and References

  1. Checler F, Vincent JP, Kitabgi P . Purification and characterization of a novel neurotensin-degrading peptidase from rat brain synaptic membranes . The Journal of Biological Chemistry . 261 . 24 . 11274–81 . August 1986 . 3525564 .
  2. Barelli H, Vincent JP, Checler F . Peripheral inactivation of neurotensin. Isolation and characterization of a metallopeptidase from rat ileum . European Journal of Biochemistry . 175 . 3 . 481–9 . August 1988 . 3409880 . 10.1111/j.1432-1033.1988.tb14220.x . free .
  3. Checler F, Barelli H, Vincent JP . Tissue distribution of a novel neurotensin-degrading metallopeptidase. An immunological approach using monospecific polyclonal antibodies . The Biochemical Journal . 257 . 2 . 549–54 . January 1989 . 2649078 . 1135613 .

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