Tachykinin receptor explained

There are three known mammalian tachykinin receptors termed NK₁, NK₂ and NK₃. All are members of the 7 transmembrane G-protein coupled receptor family and induce the activation of phospholipase C, producing inositol triphosphate (so called G_q-coupled).

Inhibitors of NK-1, known as NK-1 receptor antagonists, can be used as antiemetic agents, such as the drug aprepitant.^[1]

Binding

The genes and receptor ligands are as follows:^[2]

Receptor	Gene	Preferred ligand	-				-				-			neurokinin B

(Hökfelt et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000)

See also

• Substance P
• G protein coupled receptors

External links

• Web site: Tachykinin Receptors . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology .

Notes and References

1. Web site: Aprepitant. NICE. 2020-05-10.
2. Maggi CA . The mammalian tachykinin receptors . General Pharmacology . 26 . 5 . 911–44 . September 1995 . 7557266 . 10.1016/0306-3623(94)00292-U .