NEUROD2 explained

Neurogenic differentiation factor 2 is a protein that in humans is encoded by the NEUROD2 gene.^{[1] [2]}

Function

This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.^[2]

Interactions

NEUROD2 has been shown to interact with Protein kinase N1.^[3]

Further reading

• McCormick MB, Tamimi RM, Snider L, Asakura A, Bergstrom D, Tapscott SJ . NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family . Molecular and Cellular Biology . 16 . 10 . 5792–800 . Oct 1996 . 8816493 . 231580 . 10.1128/mcb.16.10.5792.
• Kume H, Maruyama K, Shinozaki K, Kuzume H, Obata K . Phosphorylation and spatiotemporal distribution of KW8 (NDRF/NeuroD2), a NeuroD family basic helix-loop-helix protein . Brain Research. Molecular Brain Research . 60 . 1 . 107–14 . Sep 1998 . 9748526 . 10.1016/S0169-328X(98)00176-4 .
• Kitamura T, Miyachi T, Nakamura S, Kawakami H . Identification and analysis of the promoter region of the human NeuroD-related factor (NDRF)1 . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1445 . 1 . 142–7 . Apr 1999 . 10209266 . 10.1016/s0167-4781(99)00038-x .
• Shibata H, Oda H, Mukai H, Oishi K, Misaki K, Ohkubo H, Ono Y . Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2 . Brain Research. Molecular Brain Research . 74 . 1–2 . 126–34 . Dec 1999 . 10640683 . 10.1016/S0169-328X(99)00273-9 .
• Cousin P, Billotte J, Chaubert P, Shaw P . Physical map of 17p13 and the genes adjacent to p53 . Genomics . 63 . 1 . 60–8 . Jan 2000 . 10662545 . 10.1006/geno.1999.6062 .
• Franklin A, Kao A, Tapscott S, Unis A . NeuroD homologue expression during cortical development in the human brain . Journal of Child Neurology . 16 . 11 . 849–53 . Nov 2001 . 11732772 . 10.1177/08830738010160111201 . 20069074 .
• Westerman BA, Poutsma A, Maruyama K, Schrijnemakers HF, van Wijk IJ, Oudejans CB . The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion . Mechanisms of Development . 113 . 1 . 85–90 . Apr 2002 . 11900979 . 10.1016/S0925-4773(01)00665-7 . 11607202 .
• Westerman BA, Chhatta A, Poutsma A, van Vegchel T, Oudejans CB . NEUROD1 acts in vitro as an upstream regulator of NEUROD2 in trophoblast cells . Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1676 . 1 . 96–103 . Jan 2004 . 14732494 . 10.1016/j.bbaexp.2003.10.002 .
• Zill P, Büttner A, Eisenmenger W, Bondy B . A possible impact of the neuroD2 transcription factor on the development of drug abusing behavior . Molecular Psychiatry . 11 . 6 . 525–7 . Jun 2006 . 16607387 . 10.1038/sj.mp.4001825 . 7713810 .

Notes and References

1. Tamimi RM, Steingrimsson E, Montgomery-Dyer K, Copeland NG, Jenkins NA, Tapscott SJ . NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively . Genomics . 40 . 2 . 355–7 . Mar 1997 . 9119405 . 10.1006/geno.1996.4578 .
2. Web site: Entrez Gene: NEUROD2 neurogenic differentiation 2.
3. Shibata H, Oda H, Mukai H, Oishi K, Misaki K, Ohkubo H, Ono Y . Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2 . Brain Research. Molecular Brain Research . 74 . 1–2 . 126–34 . Dec 1999 . 10640683 . 10.1016/S0169-328X(99)00273-9 .