Neamine Explained

Neamine (neomycin A) is a degradation product of the aminoglycoside antibiotic neomycin.^[1] Several derivatives of neamine are active against susceptible and resistant Gram-positive and Gram-negative bacteria.^[2]

Notes and References

1. Neamine, an Antibacterial Degradation Product of Neomycin . June 1951 . Leach BE, Teeters CM . Journal of the American Chemical Society . 73 . 6 . 2794–2797 . 10.1021/ja01150a107 .
2. Zimmermann L, Bussière A, Ouberai M, Baussanne I, Jolivalt C, Mingeot-Leclercq MP, Décout JL . Tuning the antibacterial activity of amphiphilic neamine derivatives and comparison to paromamine homologues . Journal of Medicinal Chemistry . 56 . 19 . 7691–7705 . October 2013 . 24083676 . 10.1021/jm401148j .