Nardosinone Explained

Nardosinone is a sesquiterpene and chemical constituent of Nardostachys jatamansi.^[1] In in vitro studies, the compound has demonstrated concentration-dependent enhancement of bucladesine and staurosporine-induced neurite outgrowth.^[2] Nardosinone has similarly been demonstrated to enhance NGF-mediated neurite outgrowth and synaptogenesis from PC12D cells.^[3]

Additionally, nardosinone has demonstrated cytotoxic activity against cultured P-388 lymphocytic leukemia cells.^[4]

Notes and References

1. Schulte KE, Glauch G, Rücker G . Nardosinon, ein neuer Inhaltsstoff von Nardostachys chinensis Batalin . German . Nardosinone, a new constituent of Nardostachys chinensis Batalin . Tetrahedron Letters . 1965 . 6 . 35 . 3083–3084 . 5828044 . 10.1016/S0040-4039(01)89226-1 .
2. Li P, Matsunaga K, Yamakuni T, Ohizumi Y . Nardosinone, the first enhancer of neurite outgrowth-promoting activity of staurosporine and dibutyryl cyclic AMP in PC12D cells . Developmental Brain Research . 2003 . 145 . 2 . 177–183 . 14604758 . 10.1016/S0165-3806(03)00239-6 .
3. Li P, Matsunaga K, Yamamoto K, Yoshikawa R, Kawashima K, Ohizumi Y . Nardosinone, a novel enhancer of nerve growth factor in neurite outgrowth from PC12D cells . Neuroscience Letters . 1999 . 273 . 1 . 53–56 . 10505650 . 10.1016/S0304-3940(99)00629-1 . 19913929 .
4. Itokawa H, Masuyama K, Morita H, Takeya K . Cytotoxic sesquiterpenes from Nardostachys chinensis . Chemical & Pharmaceutical Bulletin . 1993 . 41 . 6 . 1183–1184 . 8370115 . 10.1248/cpb.41.1183 . free .