Naphthylvinylpyridine Explained

Naphthylvinylpyridine (NVP) is a naphthalene derivative that possesses anticholinergic activity similar to that of atropine. However, NVP's method of acetylcholine (ACh) antagonism involves inhibiting the enzyme choline acetyltransferase.[1]

Several NVP derivatives have been synthesized and evaluated for their ability to inhibit choline acetyltransferase and protect against nerve toxins.[2] [3]

Notes and References

  1. Haubrich . DR . Goldberg . ME . 1975 . Homovanillic acid concentration in the rat brain: Effect of a choline acetyltransferase inhibitor and comparison with cholinergic and dopaminergic agents . Neuropharmacology . . 14 . 3 . 211–214 . 10.1016/0028-3908(75)90007-6 . 1134625 . 28216329.
  2. Cozzari . Costantino . Hartman . BK . 1983 . Synthesis of a naphthylvinylpyridine derivative and its use for affinity chromatography of choline acetyltransferase . Analytical Biochemistry . . 133 . 1 . 120–125 . 10.1016/0003-2697(83)90231-2 . 6638474.
  3. Gray. AP . Henderson . TR . 1988 . Approaches to protection against nerve agent poisoning . J Med Chem . 31 . 4 . 807–814 . Dynamac Corporation . 10.1021/jm00399a022. 3351860.

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