Naphthomycin Explained

Naphthomycins are a group of closely related antimicrobial chemical compounds isolated from Streptomyces. They are considered a subclass of ansamycins.

Members include:

• Naphthomycin A^{[1] [2]}
• Naphthomycin B^[3]
• Naphthomycin C^[3]
• Naphthomycin D
• Naphthomycin E
• Naphthomycin F
• Naphthomycin G
• Naphthomycin H^[4]
• Naphthomycin I^[5]
• Naphthomycin J^[5]
• Naphthomycin K^[6]
• Naphthomycin L^[7]
• Naphthomycin M^[7]
• Naphthomycin N^[7]

Notes and References

1. Balerna, M. . Keller-Schierlein, W. . Martius, C. . Wolf, H. . Zähner, H. . Arch. Mikrobiol. . Metabolic products of microorganisms. 72. Naphthomycin, an antimetabolite of vitamin K . 65 . 303–17 . 1969 . 4988744 . 4 . 10.1007/BF00412210. 31145406 .
2. Naphthomycin, a novel ansa macrocyclic metabolite. Proton NMR spectra and structural elucidation using lanthanide shift reagent . J Antibiot . 28 . 85–86 . 1975 . 10.7164/antibiotics.28.85 . 805115 . Williams . TH . 1. free .
3. 6874565 . 1983 . Keller-Schierlein . W . Meyer . M . Zeeck . A . Damberg . M . Machinek . R . Zähner . H . Lazar . G . Isolation and structural elucidation of naphthomycins B and C . 36 . 5 . 484–92 . The Journal of Antibiotics . 10.7164/antibiotics.36.484. free .
4. 4030505 . 1985 . Mukhopadhyay . T . Franco . CM . Reddy . GC . Ganguli . BN . Fehlhaber . HW . A new ansamycin antibiotic, naphthomycin H from a Streptomyces species Y-83,40369 . 38 . 7 . 948–51 . The Journal of Antibiotics . 10.7164/antibiotics.38.948. free .
5. 9820235 . 1998 . Hooper . AM . Rickards . RW . 3-amino-5-hydroxybenzoic acid in antibiotic biosynthesis. XI. Biological origins and semisynthesis of thionaphthomycins, and the structures of naphthomycins I and J . 51 . 9 . 845–51 . The Journal of Antibiotics . 10.7164/antibiotics.51.845. free .
6. 10.1038/ja.2007.84 . A Novel Ansamycin, Naphthomycin K from Streptomyces sp . 2007 . Lu . Chunhua . Shen . Yuemao . The Journal of Antibiotics . 60 . 10 . 649–53 . 17965482. free .
7. 22742732 . 2012 . Yang . YH . Fu . XL . Li . LQ . Zeng . Y . Li . CY . He . YN . Zhao . PJ . Naphthomycins L-N, ansamycin antibiotics from Streptomyces sp. CS . 75 . 7 . 1409–13 . 10.1021/np300109s . Journal of Natural Products.