Nantenine Explained

Nantenine is an alkaloid found in the plant Nandina domestica[1] as well as some Corydalis species.[2] It is an antagonist of both the α1-adrenergic receptor[3] and the serotonin 5-HT2A receptor,[4] and blocks both the behavioral and physiological effects of MDMA in animals.[5]

Notes and References

  1. Shoji N, Umeyama A, Takemoto T, Ohizumi Y . Serotonergic receptor antagonist from Nandina domestica Thunberg . Journal of Pharmaceutical Sciences . 73 . 4 . 568–70 . April 1984 . 6726648 . 10.1002/jps.2600730435.
  2. Kiryakov HG, Iskrenova E, Daskalova E, Kuzmanov B, Evstatieva L . Alkaloids of Corydalis slivenensis . Planta Medica . 44 . 3 . 168–70 . March 1982 . 17402105 . 10.1055/s-2007-971432 .
  3. Indra B, Matsunaga K, Hoshino O, Suzuki M, Ogasawara H, Ohizumi Y . Structure-activity relationship studies with (+/-)-nantenine derivatives for alpha1-adrenoceptor antagonist activity . European Journal of Pharmacology . 437 . 3 . 173–8 . February 2002 . 11890906 . 10.1016/S0014-2999(02)01303-1 .
  4. Chaudhary S, Pecic S, Legendre O, Navarro HA, Harding WW . (+/-)-Nantenine analogs as antagonists at human 5-HT(2A) receptors: C1 and flexible congeners . Bioorganic & Medicinal Chemistry Letters . 19 . 9 . 2530–2 . May 2009 . 19328689 . 10.1016/j.bmcl.2009.03.048 . 2677726.
  5. Fantegrossi WE, Kiessel CL, Leach PT, Van Martin C, Karabenick RL, Chen X, Ohizumi Y, Ullrich T, Rice KC, Woods JH . Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice . Psychopharmacology . 173 . 3–4 . 270–7 . May 2004 . 14740148 . 10.1007/s00213-003-1741-2 . 2027.42/46360 . 8425621 . free .

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