Naloxol Explained

Naloxol is an opioid antagonist closely related to naloxone. It exists in two isomeric forms, α-naloxol and β-naloxol.

α-naloxol is a human metabolite of naloxone.^[1] Synthetically, α-naloxol can be prepared from naloxone by reduction of the ketone group, and β-naloxol can be prepared from α-naloxol by a Mitsunobu reaction.^[2]

Naloxol can be said to be the oxymorphol analogue of naloxone.

See also

• Naloxegol

Notes and References

1. Metabolites of naloxone in human urine . Weinstein, S. H. . Pfeffer, M. . Schor, J. M. . Indindoli, L. . Mintz, M. . Journal of Pharmaceutical Sciences . 1971 . 60 . 10 . 1567–1568 . 10.1002/jps.2600601030 . 5129377.
2. 10.1016/S0040-4020(01)85541-1 . Stereoselective synthesis of β-naltrexol, β-naloxol β-naloxamine, β-naltrexamine and related compounds by the application of the mitsunobu reac . 1994 . Simon . C . Tetrahedron . 50 . 32 . 9757–9768.