Naftidrofuryl Explained

Naftidrofuryl (INN), also known as nafronyl or as the oxalate salt naftidrofuryl oxalate or nafronyl oxalate, is a vasodilator used in the management of peripheral and cerebral vascular disorders. It is also claimed to enhance cellular oxidative capacity. The drug act as a selective antagonist of 5-HT2 receptors (with action as an inverse agonist of the 5-HT2A receptor specifically characterized).[1] [2] [3] Naftidrofuryl is also licensed for the treatment of intermittent claudication due to peripheral arterial disease.

Naftidrofuryl is marketed under a variety of trade names, including Artocoron, Azunaftil, Di-Actane, Dusodril, Enelbin, Frilix, Gevatran, Iridus, Iridux, Luctor, Nafti, Naftilong, Naftodril, Nafoxal, Praxilene, Sodipryl retard, and Vascuprax.

Historically, it has been used to treat sudden idiopathic hearing loss and acute tinnitus.[4]

Naftidrofuryl may be effective for relieving the pain of muscle cramps.[5]

Adverse Effects

Naftidrofuryl has been associated with nausea, abdominal pain and rash. Rarely, hepatitis and liver failure have been reported.[6]

See also

Notes and References

  1. Book: Lanzer P, Topol EJ . Pan Vascular Medicine: Integrated Clinical Management. 20 December 2013. Springer. 978-3-642-56225-9. 1394–.
  2. Book: Morton IK, Hall JM . Concise Dictionary of Pharmacological Agents: Properties and Synonyms. 6 December 2012. Springer Science & Business Media. 978-94-011-4439-1. 147–.
  3. Aly SA, Hossain M, Bhuiyan MA, Nakamura T, Nagatomo T . Assessment of binding affinity to 5-hydroxytryptamine 2A (5-HT2A) receptor and inverse agonist activity of naftidrofuryl: comparison with those of sarpogrelate . Journal of Pharmacological Sciences . 110 . 4 . 445–50 . August 2009 . 19672037 . 10.1254/jphs.09124FP . free .
  4. Web site: DER ARZNEIMITTELBRIEF: Infusionstherapie beim idiopathischen Hörsturz? Dextran Dextran Hörsturz Hydroxyethylstärke Pentoxifyllin Pentoxifyllin Procain Taprosten. www.der-arzneimittelbrief.de.
  5. Katzberg HD, Khan AH, So YT . Assessment: symptomatic treatment for muscle cramps (an evidence-based review): report of the therapeutics and technology assessment subcommittee of the American academy of neurology . Neurology . 74 . 8 . 691–6 . February 2010 . 20177124 . 10.1212/WNL.0b013e3181d0ccca . free .
  6. Web site: Naftidrofuryl Oxalate. Martindale: The Complete Drug Reference. Pharmaceutical Press. 14 January 2014. 6 August 2014. Brayfield A.

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