NAD(P)H dehydrogenase (quinone) explained
| NAD(P)H dehydrogenase (quinone) |
| Ec Number: | 1.6.5.2 |
| Cas Number: | 9032-20-6 |
| Go Code: | 0003955 |
| Width: | 270 |
In enzymology, a NAD(P)H dehydrogenase (quinone) is an enzyme that catalyzes the chemical reaction
NAD(P)H + H+ + a quinone
NAD(P)
+ + a hydroquinone
The 4 substrates of this enzyme are NADH, NADPH, H+, and quinone, whereas its 3 products are NAD+, NADP+, and hydroquinone.
This enzyme belongs to the family of oxidoreductases, specifically those acting on NADH or NADPH with a quinone or similar compound as acceptor. The systematic name of this enzyme class is NAD(P)H:quinone oxidoreductase. Other names in common use include menadione reductase, phylloquinone reductase, quinone reductase, dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate,, quinone), DT-diaphorase, flavoprotein NAD(P)H-quinone reductase, menadione oxidoreductase, NAD(P)H dehydrogenase, NAD(P)H menadione reductase, NAD(P)H-quinone dehydrogenase, NAD(P)H-quinone oxidoreductase, NAD(P)H: (quinone-acceptor)oxidoreductase, NAD(P)H: menadione oxidoreductase, NADH-menadione reductase, naphthoquinone reductase, p-benzoquinone reductase, reduced NAD(P)H dehydrogenase, viologen accepting pyridine nucleotide oxidoreductase, vitamin K reductase, diaphorase, reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase, vitamin-K reductase, NAD(P)H2 dehydrogenase (quinone), NQO1, QR1, and NAD(P)H:(quinone-acceptor) oxidoreductase. This enzyme participates in biosynthesis of steroids. It employs one cofactor, FAD. At least one compound, Dicumarol is known to inhibit this enzyme.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .
References
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- Braun M, Bungert S, Friedrich T . 1998 . Characterization of the overproduced NADH dehydrogenase fragment of the NADH:ubiquinone oxidoreductase (complex I) from Escherichia coli . Biochemistry . 37 . 1861 - 7 . 9485311 . 10.1021/bi971176p . 7 .
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- Li R, Bianchet MA, Talalay P, Amzel LM . 1995 . The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction . Proc. Natl. Acad. Sci. U.S.A. . 92 . 8846 - 50 . 7568029 . 10.1073/pnas.92.19.8846 . 19 . 41064 . 1995PNAS...92.8846L . free .
