N-acetyllactosamine synthase explained

N-acetyllactosamine synthase
Ec Number:2.4.1.90
Cas Number:9054-94-8

N-acetyllactosamine synthase is a galactosyltransferase enzyme.[1] [2] [3] [4] [5] [6] It is a component of lactose synthase This enzyme modifies the connection between two molecule UDP-galactose and N-actyl-D-glucosamine and generates two different molecules UDP and N-acetyllactosamine as products.[7] The main function of the enzyme is associated with the biosynthesis of glycoproteins and glycolipids in both human and animals. In human, the activity of this enzyme can be found in Golgi apparatus.

It is classified under .

The lack of this enzyme leads to glycolysation[8] [9] which is a serious neurological disease. The nature of the disease causes fluid in the brain, abnormal inflammatory response and abnormal bleeding issues.

See also

Notes and References

  1. Deshmukh DS, Bear WD, Soifer D . Isolation and characterization of an enriched Golgi fraction from rat brain . Biochimica et Biophysica Acta (BBA) - General Subjects . 542 . 2 . 284–95 . August 1978 . 99178 . 10.1016/0304-4165(78)90024-7 .
  2. Helting T, Erbing B . Galactosyltransfer in mouse mastocytoma: purification and properties of N-acetyllactosamine synthetase . Biochimica et Biophysica Acta (BBA) - Enzymology . 293 . 1 . 94–104 . January 1973 . 4631039 . 10.1016/0005-2744(73)90379-3 .
  3. Book: Hill RL, Brew K . Advances in Enzymology and Related Areas of Molecular Biology . Lactose synthetase . Advances in Enzymology and Related Areas of Molecular Biology . 43 . 411–90 . 1975 . 812340 . 10.1002/9780470122884.ch5 . 9780470122884 .
  4. Humphreys-Beher MG . Isolation and characterization of UDP-galactose:N-acetylglucosamine 4 beta-galactosyltransferase activity induced in rat parotid glands treated with isoproterenol . The Journal of Biological Chemistry . 259 . 9 . 5797–802 . May 1984 . 10.1016/S0021-9258(18)91084-7 . 6201486 . free .
  5. Schachter H, Jabbal I, Hudgin RL, Pinteric L, McGuire EJ, Roseman S . Intracellular localization of liver sugar nucleotide glycoprotein glycosyltransferases in a Golgi-rich fraction . The Journal of Biological Chemistry . 245 . 5 . 1090–100 . March 1970 . 10.1016/S0021-9258(18)63293-4 . 4392041 . free .
  6. Book: Handbook of glycosyltransferases and related genes . Naoyuki . Taniguchi . Koichi . Honke . Minoru . Fukuda . vanc . Springer . 1st . 2002 . 443170311X.
  7. Book: 2006. Schomburg D, Schomburg I, Chang A . 10.1007/3-540-30439-8. 27. 978-3-540-26583-2. Springer Handbook of Enzymes .
  8. Hansske B, Thiel C, Lübke T, Hasilik M, Höning S, Peters V, Heidemann PH, Hoffmann GF, Berger EG, von Figura K, Körner C . 6 . Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId . The Journal of Clinical Investigation . 109 . 6 . 725–33 . March 2002 . 11901181 . 10.1172/jci0214010 . 150909 .
  9. Reily C, Stewart TJ, Renfrow MB, Novak J . Glycosylation in health and disease . Nature Reviews. Nephrology . 15 . 6 . 346–366 . June 2019 . 30858582 . 6590709 . 10.1038/s41581-019-0129-4 .

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