MTPN explained

Myotrophin is a protein that in humans is encoded by the MTPN gene.^{[1] [2]}

Interactions

MTPN has been shown to interact with RELA^[3] and REL.^[3]

Further reading

• Taoka M . A rat cerebellar protein containing the cdc10/SWI6 motif . Eur. J. Biochem. . 207 . 2 . 615–20 . 1992 . 1633812 . 10.1111/j.1432-1033.1992.tb17088.x . vanc. Yamakuni T . Song SY . 3 . Yamakawa . Yoshio . Seta . Kazuo . Okuyama . Tsuneo . Isobe . Toshiaki . free .
• Sil P, Misono K, Sen S . Myotrophin in human cardiomyopathic heart . Circ. Res. . 73 . 1 . 98–108 . 1993 . 8508536 . 10.1161/01.res.73.1.98. free .
• Sivasubramanian N, Adhikary G, Sil PC, Sen S . Cardiac myotrophin exhibits rel/NF-kappa B interacting activity in vitro . J. Biol. Chem. . 271 . 5 . 2812–6 . 1996 . 8576259 . 10.1074/jbc.271.5.2812 . free .
• Anderson KM . cDNA sequence and characterization of the gene that encodes human myotrophin/V-1 protein, a mediator of cardiac hypertrophy . J. Mol. Cell. Cardiol. . 31 . 4 . 705–19 . 1999 . 10329199 . 10.1006/jmcc.1998.0903 . vanc. Berrebi-Bertrand I . Kirkpatrick RB . 3 . McQueney . MS . Underwood . DC . Rouanet . S . Chabot-Fletcher . M .
• Hartley JL, Temple GF, Brasch MA . DNA Cloning Using In Vitro Site-Specific Recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Wiemann S . Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 . vanc. Weil B . Wellenreuther R . 3 . Gassenhuber . J . Glassl . S . Ansorge . W . Böcher . M . Blöcker . H . Bauersachs . S .
• Simpson JC . Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing . EMBO Rep. . 1 . 3 . 287–92 . 2001 . 11256614 . 10.1093/embo-reports/kvd058 . 1083732 . vanc. Wellenreuther R . Poustka A . 3 . Pepperkok . R . Wiemann . S .
• Knuefermann P . Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers . J. Biol. Chem. . 277 . 26 . 23888–97 . 2002 . 11971907 . 10.1074/jbc.M202937200 . vanc. Chen P . Misra A . 3 . Shi . SP . Abdellatif . M . Sivasubramanian . N . free.
• Gupta S, Sen S . Myotrophin-kappaB DNA interaction in the initiation process of cardiac hypertrophy . Biochim. Biophys. Acta . 1589 . 3 . 247–60 . 2002 . 12031792 . 10.1016/S0167-4889(02)00178-7 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . vanc. Feingold EA . Grouse LH . 3 . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M. free .
• Scherer SW . Human Chromosome 7: DNA Sequence and Biology . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 10.1126/science.1083423 . 2882961 . vanc. Cheung J . MacDonald JR . 3 . Osborne . LR . Nakabayashi . K . Herbrick . JA . Carson . AR . Parker-Katiraee . L . Skaug . J . 2003Sci...300..767S.
• Hillier LW . The DNA sequence of human chromosome 7 . Nature . 424 . 6945 . 157–64 . 2003 . 12853948 . 10.1038/nature01782 . vanc. Fulton RS . Fulton LA . 3 . Graves . Tina A. . Pepin . Kymberlie H. . Wagner-Mcpherson . Caryn . Layman . Dan . Maas . Jason . Jaeger . Sara . 2003Natur.424..157H. free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . vanc. Suzuki Y . Nishikawa T . 3 . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . vanc. Wagner L . Feingold EA . 3 . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Wiemann S . From ORFeome to Biology: A Functional Genomics Pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 . vanc. Arlt D . Huber W . 3 . Wellenreuther . R . Schleeger . S . Mehrle . A . Bechtel . S . Sauermann . M . Korf . U .
• Mehrle A . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 . vanc. Rosenfelder H . Schupp I . 3 . Del Val . C . Arlt . D . Hahne . F . Bechtel . S . Simpson . J . Hofmann . O .
• Xiong Z . An unconventional antigen translated by a novel internal ribosome entry site elicits antitumor humoral immune reactions . J. Immunol. . 177 . 7 . 4907–16 . 2006 . 16982933 . 10.4049/jimmunol.177.7.4907. vanc. Liu E . Yan Y . 3 . Silver . RT . Yang . F . Chen . IH . Chen . Y . Verstovsek . S . Wang . H . 3902139.
• Ewing RM . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 . vanc. Chu P . Elisma F . 3 . Li . Hongyan . Taylor . Paul . Climie . Shane . McBroom-Cerajewski . Linda . Robinson . Mark D . O'Connor . Liam .

Notes and References

1. Mitra S, Timur AA, Gupta S, Wang Q, Sen S . Assignment of myotrophin to human chromosome band 7q33→q35 by in situ hybridization . Cytogenet Cell Genet . 93 . 1–2 . 151–2 . July 2001. 11474205 . 10.1159/000056974 . 30646120 .
2. Web site: Entrez Gene: MTPN myotrophin.
3. Knuefermann . Pascal . Chen Peter . Misra Arunima . Shi Shu-Ping . Abdellatif Maha . Sivasubramanian Natarajan . June 2002. Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers . J. Biol. Chem. . 277 . 26 . 23888–97 . United States. 0021-9258. 11971907 . 10.1074/jbc.M202937200 . free .