Myosin-heavy-chain kinase explained

myosin heavy chain kinase
Ec Number:	2.7.11.7
Cas Number:	64763-54-8
Go Code:	0016905

In enzymology, a myosin-heavy-chain kinase is an enzyme that catalyzes the chemical reaction

ATP + [myosin heavy-chain]

\rightleftharpoons ADP + [myosin heavy-chain] phosphate

Thus, the two substrates of this enzyme are ATP and myosin heavy-chain, whereas its two products are ADP and myosin heavy-chain phosphate.

This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain oxygen atom of serine or threonine residues in proteins (protein-serine/threonine kinases). The systematic name of this enzyme class is ATP:[myosin heavy-chain] O-phosphotransferase. Other names in common use include

• ATP:myosin-heavy-chain O-phosphotransferase
• calmodulin-dependent myosin heavy chain kinase
• MHCK
• MIHC kinase
• myosin heavy chain kinase
• myosin I heavy-chain kinase
• myosin II heavy-chain kinase
• [myosin-heavy-chain] kinase
• myosin heavy chain kinase A
• STK6.

References

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• ((Hammer JA III)), Albanesi JP, Korn ED . 1983 . Purification and characterization of a myosin I heavy chain kinase from Acanthamoeba castellanii . J. Biol. Chem. . 258 . 10168–75 . 6309772 . 16 . 10.1016/S0021-9258(17)44620-5 . free .
• Rieker JP, Swanljung-Collins H, Collins JH . 1987 . Purification and characterization of a calmodulin-dependent myosin heavy chain kinase from intestinal brush border . J. Biol. Chem. . 262 . 15262–8 . 2822719 . 31 . 10.1016/S0021-9258(18)48169-0 . free .
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• Ravid S, Spudich JA . 1992 . Membrane-bound Dictyostelium myosin heavy chain kinase: a developmentally regulated substrate-specific member of the protein kinase C family . Proc. Natl. Acad. Sci. U.S.A. . 89 . 5877–81 . 1321427 . 10.1073/pnas.89.13.5877 . 13 . 49400 . 1992PNAS...89.5877R . free .
• Futey LM, Medley QG, Cote GP, Egelhoff TT . 1995 . Structural analysis of myosin heavy chain kinase A from Dictyostelium. Evidence for a highly divergent protein kinase domain, an amino-terminal coiled-coil domain, and a domain homologous to the beta-subunit of heterotrimeric G proteins . J. Biol. Chem. . 270 . 523–9 . 7822274 . 10.1074/jbc.270.2.523 . 2 . free .
• Korn ED, Brzeska H . 1998 . Effect of mutating the regulatory phosphoserine and conserved threonine on the activity of the expressed catalytic domain of Acanthamoeba myosin I heavy chain kinase . Proc. Natl. Acad. Sci. U.S.A. . 95 . 4146–51 . 9539704 . 10.1073/pnas.95.8.4146 . 8 . 22456 . 1998PNAS...95.4146S . free .
• Egelhoff TT, Croft D, Steimle PA . 2005 . Actin activation of myosin heavy chain kinase A in Dictyostelium: a biochemical mechanism for the spatial regulation of myosin II filament disassembly . J. Biol. Chem. . 280 . 2879–87 . 15545285 . 10.1074/jbc.M410803200 . 4 . free .