Myeloblastin Explained

Myeloblastin
Ec Number:	3.4.21.76
Cas Number:	128028-50-2

Myeloblastin (leukocyte proteinase 3, leukocyte proteinase 4, proteinase PR-3, proteinase-3, PMNL proteinase) is an enzyme.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction: Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala- > -Val-

This enzyme is present in polymorphonuclear leukocyte granules. Downregulation of myeloblastin in promyelocytic leukemia cells was shown to induce their growth arrest and differentiation.^[4]

See also

• Proteinase 3

Notes and References

1. Martin KR, Witko-Sarsat V . Proteinase 3: the odd one out that became an autoantigen . Journal of Leukocyte Biology . 102 . 3 . 689–698 . September 2017 . 28546501 . 10.1189/jlb.3MR0217-069R . free .
2. Brubaker MJ, Groutas WC, Hoidal JR, Rao NV . Human neutrophil proteinase 3: mapping of the substrate binding site using peptidyl thiobenzyl esters . Biochemical and Biophysical Research Communications . 188 . 3 . 1318–24 . November 1992 . 1445363 . 10.1016/0006-291x(92)91375-z .
3. Kam CM, Kerrigan JE, Dolman KM, Goldschmeding R, Von dem Borne AE, Powers JC . Substrate and inhibitor studies on proteinase 3 . FEBS Letters . 297 . 1-2 . 119–23 . February 1992 . 1551417 . 10.1016/0014-5793(92)80340-m . free .
4. Bories D, Raynal MC, Solomon DH, Darzynkiewicz Z, Cayre YE . Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells . Cell . 59 . 6 . 959–68 . December 1989 . 2598267 . 10.1016/0092-8674(89)90752-6. free .